Development of a microfluidic device for performing sample preconcentration and electrospray ionization mass spectrometry

Honggu Chun, J. Scott Mellors, Jean Pierre Alarie, J. Michael Ramsey

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We report on a microfabricated device for sensitive mass spectrometry (MS) by coupling sample preconcentration and electrospray ionization (ESI) in a glass microchip. The device allows highly efficient cation-selective electropreconcentration to be performed by surface coating of a micro-nano-microchannel structure with a positively charged polymer, polyE-323, which also prevents protein/peptide adsorption in the channel. An integrated electrokinetic hydraulic pump enables direct ESI at the monolithic spray tip with no dead volume. Sample preconcentration and enhanced MS signal have been demonstrated with Rhodamine 6G.

Original languageEnglish
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1716-1718
Number of pages3
ISBN (Print)9780979806421
Publication statusPublished - 2009
Externally publishedYes
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of
Duration: 2009 Nov 12009 Nov 5

Publication series

NameProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
CountryKorea, Republic of
CityJeju
Period09/11/109/11/5

Keywords

  • Electrospray ionization
  • Mass spectrometry
  • Preconcentration

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Chun, H., Mellors, J. S., Alarie, J. P., & Ramsey, J. M. (2009). Development of a microfluidic device for performing sample preconcentration and electrospray ionization mass spectrometry. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1716-1718). (Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.