Development of a microfluidic device for performing sample preconcentration and capillary electrophoresis separation

Honggu Chun, J. P. Alarie, J. M. Ramsey

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report on a microfabricated device for sample preconcentration and capillary electrophoresis (CE) separation in a glass microchip. The device allows highly efficient anion-selective preconcentration to be performed with a micro-nano-microchannel structure. An integrated cross channel enables gate-injection of the preconcentrated sample into the analysis channel for CE separation. Sample preconcentration and corresponding enhanced CE separation signal have been demonstrated with TRITC-tagged peptides.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages1727-1729
Number of pages3
Publication statusPublished - 2010
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: 2010 Oct 32010 Oct 7

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume3

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/10/310/10/7

Keywords

  • Electrophoresis
  • Preconcentration
  • Separation

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Chun, H., Alarie, J. P., & Ramsey, J. M. (2010). Development of a microfluidic device for performing sample preconcentration and capillary electrophoresis separation. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (pp. 1727-1729). (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 3).