Development of a novel normoxic polymer gel dosimeter (TENOMAG)

Sam Ju Cho, Dongho Shin, Hyun Do Huh, Sang Hoon Lee, Sang Wook Lim, Jisun Jang, Kwang Hwan Cho, Hun Joo Shin, Sooil Kwon, Hyong Geun Yun, Sang Mo Yun, Dong Oh Shin, Dae-Sik Yang, Young Je Park, Chul Yong Kim, Suk Lee

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Abstract

In recent years, the verification of the three-dimensional (3-D) distribution of the absorbed dose in the tumor volume has been significantly considered in a radiation-therapy treatment plan. This study produced a polymer gel under a normoxic condition by using antioxidants, instead of using a polymer gel dosimeter, that can only be applied under a hypoxic condition using nitrogen gas. Also, this study investigated the characteristics of normoxic polymer gel for various compositions of the gel compound samples to produce practical polymer gels and composite polymer gels with five different compositions. Magnetic resonance images, R2 mapping images, dose-R2 response curves were analyzed for various composition ratios, and dose distributions. This study prepared polymer gels (Tetrakis hydroxymethyl phosphonium chloride-normoxic methacrylic acid-gelatin, TENOMAG) under a normoxic condition by using antioxidants and obtained a composition ratio that could be applied practically in clinics.

Original languageEnglish
Pages (from-to)1798-1804
Number of pages7
JournalJournal of the Korean Physical Society
Volume51
Issue number5
Publication statusPublished - 2007 Nov 1

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Keywords

  • Dose-R2 response curve
  • Normoxic polymer gel
  • Radiotherapy
  • Three-dimensional dosimeter

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Cho, S. J., Shin, D., Huh, H. D., Lee, S. H., Lim, S. W., Jang, J., Cho, K. H., Shin, H. J., Kwon, S., Yun, H. G., Yun, S. M., Shin, D. O., Yang, D-S., Park, Y. J., Kim, C. Y., & Lee, S. (2007). Development of a novel normoxic polymer gel dosimeter (TENOMAG). Journal of the Korean Physical Society, 51(5), 1798-1804.