Development of a novel normoxic polymer gel dosimeter (TENOMAG)

Sam Ju Cho; Dongho Shin; Hyun Do Huh; Sang Hoon Lee; Sang Wook Lim; Jisun Jang; Kwang Hwan Cho; Hun Joo Shin; Sooil Kwon; Hyong Geun Yun; Sang Mo Yun; Dong Oh Shin; Dae Sik Yang; Young Je Park; Chul Yong Kim; Suk Lee

doi:10.3938/jkps.51.1798

Development of a novel normoxic polymer gel dosimeter (TENOMAG)

Sam Ju Cho, Dongho Shin, Hyun Do Huh, Sang Hoon Lee, Sang Wook Lim, Jisun Jang, Kwang Hwan Cho, Hun Joo Shin, Sooil Kwon, Hyong Geun Yun, Sang Mo Yun, Dong Oh Shin, Dae Sik Yang, Young Je Park, Chul Yong Kim, Suk Lee

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

In recent years, the verification of the three-dimensional (3-D) distribution of the absorbed dose in the tumor volume has been significantly considered in a radiation-therapy treatment plan. This study produced a polymer gel under a normoxic condition by using antioxidants, instead of using a polymer gel dosimeter, that can only be applied under a hypoxic condition using nitrogen gas. Also, this study investigated the characteristics of normoxic polymer gel for various compositions of the gel compound samples to produce practical polymer gels and composite polymer gels with five different compositions. Magnetic resonance images, R2 mapping images, dose-R2 response curves were analyzed for various composition ratios, and dose distributions. This study prepared polymer gels (Tetrakis hydroxymethyl phosphonium chloride-normoxic methacrylic acid-gelatin, TENOMAG) under a normoxic condition by using antioxidants and obtained a composition ratio that could be applied practically in clinics.

Original language	English
Pages (from-to)	1798-1804
Number of pages	7
Journal	Journal of the Korean Physical Society
Volume	51
Issue number	5
DOIs	https://doi.org/10.3938/jkps.51.1798
Publication status	Published - 2007 Nov

Keywords

Dose-R2 response curve
Normoxic polymer gel
Radiotherapy
Three-dimensional dosimeter

ASJC Scopus subject areas

Physics and Astronomy(all)

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10.3938/jkps.51.1798

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title = "Development of a novel normoxic polymer gel dosimeter (TENOMAG)",

abstract = "In recent years, the verification of the three-dimensional (3-D) distribution of the absorbed dose in the tumor volume has been significantly considered in a radiation-therapy treatment plan. This study produced a polymer gel under a normoxic condition by using antioxidants, instead of using a polymer gel dosimeter, that can only be applied under a hypoxic condition using nitrogen gas. Also, this study investigated the characteristics of normoxic polymer gel for various compositions of the gel compound samples to produce practical polymer gels and composite polymer gels with five different compositions. Magnetic resonance images, R2 mapping images, dose-R2 response curves were analyzed for various composition ratios, and dose distributions. This study prepared polymer gels (Tetrakis hydroxymethyl phosphonium chloride-normoxic methacrylic acid-gelatin, TENOMAG) under a normoxic condition by using antioxidants and obtained a composition ratio that could be applied practically in clinics.",

keywords = "Dose-R2 response curve, Normoxic polymer gel, Radiotherapy, Three-dimensional dosimeter",

author = "Cho, {Sam Ju} and Dongho Shin and Huh, {Hyun Do} and Lee, {Sang Hoon} and Lim, {Sang Wook} and Jisun Jang and Cho, {Kwang Hwan} and Shin, {Hun Joo} and Sooil Kwon and Yun, {Hyong Geun} and Yun, {Sang Mo} and Shin, {Dong Oh} and Yang, {Dae Sik} and Park, {Young Je} and Kim, {Chul Yong} and Suk Lee",

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doi = "10.3938/jkps.51.1798",

language = "English",

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AU - Cho, Sam Ju

AU - Shin, Dongho

AU - Huh, Hyun Do

AU - Lee, Sang Hoon

AU - Lim, Sang Wook

AU - Jang, Jisun

AU - Cho, Kwang Hwan

AU - Shin, Hun Joo

AU - Kwon, Sooil

AU - Yun, Hyong Geun

AU - Yun, Sang Mo

AU - Shin, Dong Oh

AU - Yang, Dae Sik

AU - Park, Young Je

AU - Kim, Chul Yong

AU - Lee, Suk

PY - 2007/11

Y1 - 2007/11

N2 - In recent years, the verification of the three-dimensional (3-D) distribution of the absorbed dose in the tumor volume has been significantly considered in a radiation-therapy treatment plan. This study produced a polymer gel under a normoxic condition by using antioxidants, instead of using a polymer gel dosimeter, that can only be applied under a hypoxic condition using nitrogen gas. Also, this study investigated the characteristics of normoxic polymer gel for various compositions of the gel compound samples to produce practical polymer gels and composite polymer gels with five different compositions. Magnetic resonance images, R2 mapping images, dose-R2 response curves were analyzed for various composition ratios, and dose distributions. This study prepared polymer gels (Tetrakis hydroxymethyl phosphonium chloride-normoxic methacrylic acid-gelatin, TENOMAG) under a normoxic condition by using antioxidants and obtained a composition ratio that could be applied practically in clinics.

AB - In recent years, the verification of the three-dimensional (3-D) distribution of the absorbed dose in the tumor volume has been significantly considered in a radiation-therapy treatment plan. This study produced a polymer gel under a normoxic condition by using antioxidants, instead of using a polymer gel dosimeter, that can only be applied under a hypoxic condition using nitrogen gas. Also, this study investigated the characteristics of normoxic polymer gel for various compositions of the gel compound samples to produce practical polymer gels and composite polymer gels with five different compositions. Magnetic resonance images, R2 mapping images, dose-R2 response curves were analyzed for various composition ratios, and dose distributions. This study prepared polymer gels (Tetrakis hydroxymethyl phosphonium chloride-normoxic methacrylic acid-gelatin, TENOMAG) under a normoxic condition by using antioxidants and obtained a composition ratio that could be applied practically in clinics.

KW - Dose-R2 response curve

KW - Normoxic polymer gel

KW - Radiotherapy

KW - Three-dimensional dosimeter

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Development of a novel normoxic polymer gel dosimeter (TENOMAG)

Abstract

Keywords

ASJC Scopus subject areas

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