Development of a novel normoxic polymer gel dosimeter (TENOMAG)

Sam Ju Cho; Dongho Shin; Hyun Do Huh; Sang Hoon Lee; Sang Wook Lim; Jisun Jang; Kwang Hwan Cho; Hun Joo Shin; Sooil Kwon; Hyong Geun Yun; Sang Mo Yun; Dong Oh Shin; Dae Sik Yang; Young Je Park; Chul Yong Kim; Suk Lee

doi:10.3938/jkps.51.1798

Development of a novel normoxic polymer gel dosimeter (TENOMAG)

Sam Ju Cho, Dongho Shin, Hyun Do Huh, Sang Hoon Lee, Sang Wook Lim, Jisun Jang, Kwang Hwan Cho, Hun Joo Shin, Sooil Kwon, Hyong Geun Yun, Sang Mo Yun, Dong Oh Shin, Dae Sik Yang, Young Je Park, Chul Yong Kim, Suk Lee

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

In recent years, the verification of the three-dimensional (3-D) distribution of the absorbed dose in the tumor volume has been significantly considered in a radiation-therapy treatment plan. This study produced a polymer gel under a normoxic condition by using antioxidants, instead of using a polymer gel dosimeter, that can only be applied under a hypoxic condition using nitrogen gas. Also, this study investigated the characteristics of normoxic polymer gel for various compositions of the gel compound samples to produce practical polymer gels and composite polymer gels with five different compositions. Magnetic resonance images, R2 mapping images, dose-R2 response curves were analyzed for various composition ratios, and dose distributions. This study prepared polymer gels (Tetrakis hydroxymethyl phosphonium chloride-normoxic methacrylic acid-gelatin, TENOMAG) under a normoxic condition by using antioxidants and obtained a composition ratio that could be applied practically in clinics.

Original language	English
Pages (from-to)	1798-1804
Number of pages	7
Journal	Journal of the Korean Physical Society
Volume	51
Issue number	5
DOIs	https://doi.org/10.3938/jkps.51.1798
Publication status	Published - 2007 Nov

Keywords

Dose-R2 response curve
Normoxic polymer gel
Radiotherapy
Three-dimensional dosimeter

ASJC Scopus subject areas

Physics and Astronomy(all)

Access to Document

10.3938/jkps.51.1798

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Development of a novel normoxic polymer gel dosimeter (TENOMAG). / Cho, Sam Ju; Shin, Dongho; Huh, Hyun Do; Lee, Sang Hoon; Lim, Sang Wook; Jang, Jisun; Cho, Kwang Hwan; Shin, Hun Joo; Kwon, Sooil; Yun, Hyong Geun; Yun, Sang Mo; Shin, Dong Oh; Yang, Dae Sik; Park, Young Je; Kim, Chul Yong; Lee, Suk.

In: Journal of the Korean Physical Society, Vol. 51, No. 5, 11.2007, p. 1798-1804.

Research output: Contribution to journal › Article › peer-review

Cho, Sam Ju ; Shin, Dongho ; Huh, Hyun Do ; Lee, Sang Hoon ; Lim, Sang Wook ; Jang, Jisun ; Cho, Kwang Hwan ; Shin, Hun Joo ; Kwon, Sooil ; Yun, Hyong Geun ; Yun, Sang Mo ; Shin, Dong Oh ; Yang, Dae Sik ; Park, Young Je ; Kim, Chul Yong ; Lee, Suk. / Development of a novel normoxic polymer gel dosimeter (TENOMAG). In: Journal of the Korean Physical Society. 2007 ; Vol. 51, No. 5. pp. 1798-1804.

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abstract = "In recent years, the verification of the three-dimensional (3-D) distribution of the absorbed dose in the tumor volume has been significantly considered in a radiation-therapy treatment plan. This study produced a polymer gel under a normoxic condition by using antioxidants, instead of using a polymer gel dosimeter, that can only be applied under a hypoxic condition using nitrogen gas. Also, this study investigated the characteristics of normoxic polymer gel for various compositions of the gel compound samples to produce practical polymer gels and composite polymer gels with five different compositions. Magnetic resonance images, R2 mapping images, dose-R2 response curves were analyzed for various composition ratios, and dose distributions. This study prepared polymer gels (Tetrakis hydroxymethyl phosphonium chloride-normoxic methacrylic acid-gelatin, TENOMAG) under a normoxic condition by using antioxidants and obtained a composition ratio that could be applied practically in clinics.",

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