Development of a patient-specific 3D dose evaluation program for QA in radiation therapy

Suk Lee, Kyung Hwan Chang, Yuan Jie Cao, Jang Bo Shim, Dae-Sik Yang, Young Je Park, Won Sup Yoon, Chul Yong Kim

Research output: Contribution to journalArticle

Abstract

We present preliminary results for a 3-dimensional dose evaluation software system (<sup>P</sup> DRESS, patient-specific 3-dimensional dose real evaluation system). Scanned computed tomography (CT) images obtained by using dosimetry were transferred to the radiation treatment planning system (ECLIPSE, VARIAN, Palo Alto, CA) where the intensity modulated radiation therapy (IMRT) nasopharynx plan was designed. We used a 10 MV photon beam (CLiX, VARIAN, Palo Alto, CA) to deliver the nasopharynx treatment plan. After irradiation, the TENOMAG dosimeter was scanned using a VISTA™ scanner. The scanned data were reconstructed using VistaRecon software to obtain a 3D dose distribution of the optical density. An optical-CT scanner was used to readout the dose distribution in the gel dosimeter. Moreover, we developed the <sup>P</sup>DRESS by using Flatform, which were developed by our group, to display the 3D dose distribution by loading the DICOM RT data which are exported from the radiotherapy treatment plan (RTP) and the optical-CT reconstructed VFF file, into the independent <sup>P</sup>DRESS with an ioniz ation chamber and EBT film was used to compare the dose distribution calculated from the RTP with that measured by using a gel dosimeter. The agreement between the normalized EBT, the gel dosimeter and RTP data was evaluated using both qualitative and quantitative methods, such as the isodose distribution, dose difference, point value, and profile. The profiles showed good agreement between the RTP data and the gel dosimeter data, and the precision of the dose distribution was within ±3%. The results from this study showed significantly discrepancies between the dose distribution calculated from the treatment plan and the dose distribution measured by a TENOMAG gel and by scanning with an optical CT scanner. The 3D dose evaluation software system (<sup>P</sup> DRESS, patient specific dose real evaluation system), which were developed in this study evaluates the accuracies of the three-dimensional dose distributions. Further applications of the system utility are expected to result from future studies.

Original languageEnglish
Pages (from-to)859-866
Number of pages8
JournalJournal of the Korean Physical Society
Volume66
Issue number6
DOIs
Publication statusPublished - 2015 Apr 16

Fingerprint

radiation therapy
dosage
evaluation
dosimeters
gels
tomography
scanners
computer programs
optical density
photon beams
profiles
files
planning
readout
chambers
irradiation
scanning

Keywords

  • <sup>P</sup> DRESS
  • 3D dose evaluation program
  • Gel dosimeter
  • Optical CT scanner
  • Radiotherapy

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Development of a patient-specific 3D dose evaluation program for QA in radiation therapy. / Lee, Suk; Chang, Kyung Hwan; Cao, Yuan Jie; Shim, Jang Bo; Yang, Dae-Sik; Park, Young Je; Yoon, Won Sup; Kim, Chul Yong.

In: Journal of the Korean Physical Society, Vol. 66, No. 6, 16.04.2015, p. 859-866.

Research output: Contribution to journalArticle

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abstract = "We present preliminary results for a 3-dimensional dose evaluation software system (P DRESS, patient-specific 3-dimensional dose real evaluation system). Scanned computed tomography (CT) images obtained by using dosimetry were transferred to the radiation treatment planning system (ECLIPSE, VARIAN, Palo Alto, CA) where the intensity modulated radiation therapy (IMRT) nasopharynx plan was designed. We used a 10 MV photon beam (CLiX, VARIAN, Palo Alto, CA) to deliver the nasopharynx treatment plan. After irradiation, the TENOMAG dosimeter was scanned using a VISTA™ scanner. The scanned data were reconstructed using VistaRecon software to obtain a 3D dose distribution of the optical density. An optical-CT scanner was used to readout the dose distribution in the gel dosimeter. Moreover, we developed the PDRESS by using Flatform, which were developed by our group, to display the 3D dose distribution by loading the DICOM RT data which are exported from the radiotherapy treatment plan (RTP) and the optical-CT reconstructed VFF file, into the independent PDRESS with an ioniz ation chamber and EBT film was used to compare the dose distribution calculated from the RTP with that measured by using a gel dosimeter. The agreement between the normalized EBT, the gel dosimeter and RTP data was evaluated using both qualitative and quantitative methods, such as the isodose distribution, dose difference, point value, and profile. The profiles showed good agreement between the RTP data and the gel dosimeter data, and the precision of the dose distribution was within ±3{\%}. The results from this study showed significantly discrepancies between the dose distribution calculated from the treatment plan and the dose distribution measured by a TENOMAG gel and by scanning with an optical CT scanner. The 3D dose evaluation software system (P DRESS, patient specific dose real evaluation system), which were developed in this study evaluates the accuracies of the three-dimensional dose distributions. Further applications of the system utility are expected to result from future studies.",
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