Development of a three-dimensional brain-on-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer's disease

J. S. Park, B. K. Lee, G. S. Jeong, Changjoon Lee, Sang Hoon Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In vitro models for neurologic diseases have been highly demanded for better understanding of pathology and strategies for treatment of the diseases such as Alzheimer's disease (AD); however, there have been limits in mimicking in vivo microenvironment on in vitro system. Here, we have developed a microfluidic chip based on three-dimensional (3D) neurospheroids providing interstitial level of flow mimicking in vivo microenvironment more closely. With this platform, we investigated the effect of flow on neurospheroids in size, neural networking, and neural differentiation. Also, we observed the effect of amyloid-β (Aβ) which is generally accepted as a major component causing AD.

Original languageEnglish
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages2524-2525
Number of pages2
ISBN (Print)9780979806476
Publication statusPublished - 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: 2014 Oct 262014 Oct 30

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period14/10/2614/10/30

Keywords

  • Alzheimer's disease
  • Brain-on-a-chip
  • Interstitial flow
  • Neurospheroid

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Park, J. S., Lee, B. K., Jeong, G. S., Lee, C., & Lee, S. H. (2014). Development of a three-dimensional brain-on-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer's disease. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 2524-2525). Chemical and Biological Microsystems Society.