Development of assessment technology for a rat myocardial infarct model using integrated PET/CT and MRI images

Sang Keun Woo, Gi Jeong Cheon, Kyeong Min Kim, Won Ho Lee, Yong Jin Lee, Min Hwan Kim, Joo Hyun Kang, Young Hoon Ji, Chang Woon Choi, Sang Moo Lim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The aim of this study was to improve quantitative assessment of rat myocardial infarct size using attenuation corrected PET polar map with gated CT image and MRI polarmap. The PET/CT images obtained with a small animal PET/CT scanner. Gating was realized with the help of an external trigger device. Contrast enhanced FLASH sequence MRI image was acquired with a 3-T clinical MRI using ECG triggering. The SUV PET image pixel size was percent variation was calculated anterior wall (ANT), septal wall (SEP), inferior wall (INF) and lateral wall (LAT) in polar map. Homogeneity was calculated no corrected PET (NC), attenuation corrected PET with CT image (AC-CT) and AC gated PET with gated CT image (gAC-gCT). TTC staining measures tissue viability used to evaluate real infarct size. The reference infarct size was defined by infarction area percentage of the total left myocardium. The infarct size for optimal size was repeated varying threshold values. The NC and AC-CT image percent variation of ANT, SEP, INF and LAT was 0.42%, 1.61%, 0.41% and 0.86% respectively. The gAC-gCT image percent variation of ANT, SEP, INF and LAT was 3.74% 1.21% 3.28% and 4.29% respectively. The gated CT AC gated PET polar map homogeneity was improved myocardial activity in anterior, inferior and lateral region. MRI based polar map with FLASH sequence at threshold lower 60% provide good result of infarct size measurement. Integrated myocardial analysis technology of high sensitive PET and high resolution MRI images may potentially facilitate the improvement of volume and attenuation correction information in cardiology.

Original languageEnglish
Title of host publicationIEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010
Pages2710-2713
Number of pages4
DOIs
Publication statusPublished - 2010
Event2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010 - Knoxville, TN, United States
Duration: 2010 Oct 302010 Nov 6

Publication series

NameIEEE Nuclear Science Symposium Conference Record
ISSN (Print)1095-7863

Conference

Conference2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010
CountryUnited States
CityKnoxville, TN
Period10/10/3010/11/6

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Woo, S. K., Cheon, G. J., Kim, K. M., Lee, W. H., Lee, Y. J., Kim, M. H., Kang, J. H., Ji, Y. H., Choi, C. W., & Lim, S. M. (2010). Development of assessment technology for a rat myocardial infarct model using integrated PET/CT and MRI images. In IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010 (pp. 2710-2713). [5874283] (IEEE Nuclear Science Symposium Conference Record). https://doi.org/10.1109/NSSMIC.2010.5874283