Development of Co-hemin MOF/chitosan composite based biosensor for rapid detection of lactose

Han Suk Choi, Xiaoguang Yang, Guicheng Liu, Dong Sup Kim, Ji Hyun Yang, Ju Hun Lee, Sung Ok Han, Jinyoung Lee, Seung Wook Kim

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


An electrochemical biosensor containing Co-hemin metal organic frameworks (Co-hemin MOF)/chitosan composite and cellobiose dehydrogenase (CDH) was developed for lactose dectection. The formation of the Co-hemin MOF was verified by scanning electron microscopy, Fourier transform infrared spectroscopy, UV–vis absorption spectroscopy and electrochemical techniques. The Co-hemin MOF/chitosan composite exhibited outstanding electrochemical performance on lactose detection with high sensitivity (102.3 μA mM−1 cm−2) and fast response (5 s). More importantly, the lower determination limit of 4 mM and the broad linear ranges of 10 to 100 mM were obtained to detect lactose. With broad linear ranges, the feasibility of dairy application of the biosensor based on Co-hemin MOF electrode was demonstrated in this study.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalJournal of the Taiwan Institute of Chemical Engineers
Publication statusPublished - 2020 Aug


  • Cellobiose dehydrogenase
  • Co-hemin
  • Electrochemical biosensor
  • Lactose
  • Metal organic frameworks

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)


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