Development of highly efficient nanocarrier-mediated delivery approaches for cancer therapy

Keunsoo Jeong, Chi Soo Kang, Youngsun Kim, Yong Deok Lee, Ick Chan Kwon, Sehoon Kim

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Nanocarriers (NCs) are a group of nano-sized vehicles devised to deliver drugs to targeted malignant tissues or organs that provide remarkably improved targeting efficiency and therapeutic efficacy for cancer therapy. A variety of NCs have been developed to accommodate appropriate loading and release of drugs with a wide spectrum of chemical and physical characteristics. In addition, physicochemical modifications to the surface or interior of NCs allow for modulation of pharmacokinetic features reflecting clinical demands. However, cancer-related mortality is still high and drug-mediated cancer treatment remains a challenging research field despite the remarkable advances in targeting efficiency and therapeutic efficacy resulting from NCs. In this review, we focus on typical approaches and recent trends in NC-mediated drug delivery systems and their potential for targeted cancer therapy.

Original languageEnglish
Pages (from-to)31-43
Number of pages13
JournalCancer Letters
Volume374
Issue number1
DOIs
Publication statusPublished - 2016 Apr 28
Externally publishedYes

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Keywords

  • Cancer therapy
  • Combination therapy
  • Drug delivery
  • Nanocarrier
  • Stimuli-activated therapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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