Development of micro Hemocytometer for human erythrocyte analysis for the early detection of cancer

Seok Chung, J. Park, Y. Lee, C. Chung, D. C. Han, J. K. Chang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

The relation between erythrocyte deformability and cancer has been proved in medical fields, but it is very difficult to systemize and commercialize the traditional schemes for erythrocyte deformability assessment. In this work, a desk-top type RBC Hemocytometer system with PDMS microchip has been developed for the assessment. Macrochannels with microfiltering structure in the microchip make the erythrocyte deformed, and with an UV optical array system and C language based image processing software, filter-pass-shape and filter-pass-velocity of erythrocytes are sequentially analyzed. In the comparative studies with blood from cancerous patients and control blood, we could obtain statistically acceptable data that can distinguish cancerous from control regardless of the cancer infected regions. To enhance the performance of the system, comparative studies changing the materials of the chip (silicon-glass, PDMS and PMMA) and sectional surface characteristics control have been accomplished with notable results. This RBC Hemocytometer system can be applied as a practical diagnostic apparatus in early detection of cancer.

Original languageEnglish
Title of host publication2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages496-499
Number of pages4
ISBN (Print)0780374800, 9780780374805
DOIs
Publication statusPublished - 2002
Externally publishedYes
Event2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Madison, United States
Duration: 2002 May 22002 May 4

Other

Other2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology
CountryUnited States
CityMadison
Period02/5/202/5/4

Fingerprint

Erythrocyte Deformability
Early Detection of Cancer
Erythrocytes
Optical Devices
Polymethyl Methacrylate
Silicon
Glass
Neoplasms
Language
Software

Keywords

  • cancer detection
  • diagnostic device
  • erythrocyte
  • PDMS microchip

ASJC Scopus subject areas

  • Biotechnology
  • Microbiology (medical)

Cite this

Chung, S., Park, J., Lee, Y., Chung, C., Han, D. C., & Chang, J. K. (2002). Development of micro Hemocytometer for human erythrocyte analysis for the early detection of cancer. In 2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings (pp. 496-499). [1002388] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MMB.2002.1002388

Development of micro Hemocytometer for human erythrocyte analysis for the early detection of cancer. / Chung, Seok; Park, J.; Lee, Y.; Chung, C.; Han, D. C.; Chang, J. K.

2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2002. p. 496-499 1002388.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chung, S, Park, J, Lee, Y, Chung, C, Han, DC & Chang, JK 2002, Development of micro Hemocytometer for human erythrocyte analysis for the early detection of cancer. in 2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings., 1002388, Institute of Electrical and Electronics Engineers Inc., pp. 496-499, 2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, Madison, United States, 02/5/2. https://doi.org/10.1109/MMB.2002.1002388
Chung S, Park J, Lee Y, Chung C, Han DC, Chang JK. Development of micro Hemocytometer for human erythrocyte analysis for the early detection of cancer. In 2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2002. p. 496-499. 1002388 https://doi.org/10.1109/MMB.2002.1002388
Chung, Seok ; Park, J. ; Lee, Y. ; Chung, C. ; Han, D. C. ; Chang, J. K. / Development of micro Hemocytometer for human erythrocyte analysis for the early detection of cancer. 2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2002. pp. 496-499
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