Development of microfluidic chip-based alginate microtube for angiogenesis

S. J. Shin, K. H. Lee, Sang Hoon Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this work, we fabricated the microfluidic chip-based micro-alginate tubes (MAT) for angiogenesis. These micro-alginate tubes could be adjusted in selfdeveloping extracellular matrix (ECM)-like networks. We have used poly(dimethylsiloxane) (PDMS) microfluidic device integrated capillary glass pipette as apparatus for micro-alginate tube generation. In addition, we evaluated the micro-alginate tube as an angiogenesis by loading calf pulmonary artery endothelial (CPAE) cells during the fabrication MHT process. From the LIVE/DEAD assay, CPAE cells survived well during the 5 days in vitro. The microfluidic chip-based micro-alginate tube, including cells or proteins, can be produced effective 3-D shaped micro-vascular for the angiogenesis.

Original languageEnglish
Title of host publication12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference
PublisherChemical and Biological Microsystems Society
Pages525-527
Number of pages3
Publication statusPublished - 2008
Event12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States
Duration: 2008 Oct 122008 Oct 16

Other

Other12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
CountryUnited States
CitySan Diego, CA
Period08/10/1208/10/16

Keywords

  • Alginate
  • Angiogenesis
  • Microtube

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Shin, S. J., Lee, K. H., & Lee, S. H. (2008). Development of microfluidic chip-based alginate microtube for angiogenesis. In 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference (pp. 525-527). Chemical and Biological Microsystems Society.