Development of part-dissolvable chitosan fibers with surface N-succinylation for wound care dressing

Guohui Sun, Chao Feng, Ming Kong, Xiaojie Cheng, Jiaojiao Bing, Guixue Xia, Zixian Bao, Hyun Jin Park, Xiguang Chen

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

To enhance the liquor absorptivity of chitosan fibers (CS-Fs), N-succinyl surface-modified chitosan fibers (NSCS-Fs) were developed and evaluated for wound healing. The NSCS-Fs exhibited cracks on the surface and high liquor absorbing capacity with absorbing–dissolvable equilibrium state in phosphate buffer solution (PBS). The bacteriostasis ratios of NSCS-Fs against E. coli, S. aureus and C. albicans were higher than 80%. No cytotoxicity has been found for mouse embryo fibroblasts (MEFs) treated with NSCS-Fs leach liquor. Acute oral toxicity and skin irritation experiment were taken to evaluate the safety of NSCS-Fs in vitro. Muscle implant study showed that NSCS-Fs were biodegradable and non-toxic in vivo. These results suggested that the surface modified NSCS-Fs had favorable biological properties and improved liquor absorptivity, indicating that they could be used as promising dressing materials for wound care.

Original languageEnglish
Pages (from-to)272-281
Number of pages10
JournalFrontiers of Materials Science
Volume9
Issue number3
DOIs
Publication statusPublished - 2015 Jun 15

Keywords

  • chitosan fiber
  • liquor absorptivity
  • part dissolvability
  • surface N-succinylation
  • wound dressing

ASJC Scopus subject areas

  • Materials Science(all)

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