Developmental pattern of the hip in patients with hereditary multiple exostoses

Ya Zhou Wang, Kwang Won Park, Chang Seon Oh, Yeong Seub Ahn, Qing Lin Kang, Sung Taek Jung, Hae Ryong Song

Research output: Contribution to journalArticle

8 Citations (Scopus)


Background: Coxa valga is a common clinical feature of hereditary multiple exostoses (HME). The current study aimed to determine the unique developmental pattern of the hip in patients with HME and evaluate the factors that influence its progression. Methods: Thirty patients (57 hips) with HME were divided into two groups according to the Hilgenreiner epiphyseal angle (HEA). Twenty-two patients (44 hips) including 13 men and 9 women were assigned to group 1 (HEA <25°), and 8 patients (13 hips) including 3 men and 5 women were assigned to group 2 (HEA ≥25°). The mean age at the initial presentation was 6.0 (4-12) years with 6.8 (4-11) years of follow-up in group 1, and 10.4 (8-13) years with 5.4 (2-9) years of follow-up in group 2. We measured the HEA, neck-shaft angle (NSA), acetabular index (AI), center-edge angle (CEA), and migration percentage (MP) for radiographic evaluation. Results: Among the hips, 50 (87.7%) hips had coxa valga and 27 (47.4%) hips had abnormal MP (42.1% were borderline and 5.3% were subluxated). There was a significant difference in the HEA and NSA between the groups (p < 0.001 and p < 0.05, respectively). The HEA significantly correlated with the development of the NSA and no correlation was found between the HEA and AI, CEA, and MP. Conclusions: There was a significant relationship between the HEA at the initial presentation and the NSA at skeletal maturity. We should consider guided growth for patients with lower HEA to prevent significant coxa valga deformity with close follow-up.

Original languageEnglish
JournalBMC Musculoskeletal Disorders
Publication statusAccepted/In press - 2015 Mar 15


  • Coxa valga
  • Development
  • Hereditary multiple exostoses
  • Hip

ASJC Scopus subject areas

  • Rheumatology
  • Orthopedics and Sports Medicine

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