Dexamethasone increases angiopoietin-1 and quiescent hematopoietic stem cells: A novel mechanism of dexamethasone-induced hematoprotection

Hyongbum Kim, Ji Young Choi, Jung Min Lee, Yoon Shin Park, Hwal Suh, Hae Ryong Song, Sangmee Ahn Jo, Inho Jo

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Angiopoietin-1 (Ang-1) is known to have hematoprotective effects by increasing the quiescence of hematopoietic stem cells. However, it remains to be determined if the upregulation of Ang-1 and the subsequent increase in the quiescence of hematopoietic stem cells are also involved in the dexamethasone (Dex)-mediated bone marrow protection. Here Western blotting and flow cytometric analyses demonstrate that Dex increases the levels of Ang-1 in mouse bone marrow and the quiescence of hematopoietic stem cells. Our data for the first time suggest that the increased quiescence of hematopoietic stem cells provides a novel mechanism of Dex-induced hematoprotection.

Original languageEnglish
Pages (from-to)3509-3514
Number of pages6
JournalFEBS Letters
Volume582
Issue number23-24
DOIs
Publication statusPublished - 2008 Oct 15

Keywords

  • Angiopoietin-1
  • Bone marrow
  • Dexamethasone
  • Hematopoietic stem cells
  • Hematoprotection

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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