Dexamethasone increases angiopoietin-1 and quiescent hematopoietic stem cells

A novel mechanism of dexamethasone-induced hematoprotection

Hyongbum Kim, Ji Young Choi, Jung Min Lee, Yoon Shin Park, Hwal Suh, Hae Ryong Song, Sangmee Ahn Jo, Inho Jo

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Angiopoietin-1 (Ang-1) is known to have hematoprotective effects by increasing the quiescence of hematopoietic stem cells. However, it remains to be determined if the upregulation of Ang-1 and the subsequent increase in the quiescence of hematopoietic stem cells are also involved in the dexamethasone (Dex)-mediated bone marrow protection. Here Western blotting and flow cytometric analyses demonstrate that Dex increases the levels of Ang-1 in mouse bone marrow and the quiescence of hematopoietic stem cells. Our data for the first time suggest that the increased quiescence of hematopoietic stem cells provides a novel mechanism of Dex-induced hematoprotection.

Original languageEnglish
Pages (from-to)3509-3514
Number of pages6
JournalFEBS Letters
Volume582
Issue number23-24
DOIs
Publication statusPublished - 2008 Oct 15

Fingerprint

Angiopoietin-1
Hematopoietic Stem Cells
Stem cells
Dexamethasone
Bone
Bone Marrow
Up-Regulation
Western Blotting

Keywords

  • Angiopoietin-1
  • Bone marrow
  • Dexamethasone
  • Hematopoietic stem cells
  • Hematoprotection

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

Cite this

Dexamethasone increases angiopoietin-1 and quiescent hematopoietic stem cells : A novel mechanism of dexamethasone-induced hematoprotection. / Kim, Hyongbum; Choi, Ji Young; Lee, Jung Min; Park, Yoon Shin; Suh, Hwal; Song, Hae Ryong; Jo, Sangmee Ahn; Jo, Inho.

In: FEBS Letters, Vol. 582, No. 23-24, 15.10.2008, p. 3509-3514.

Research output: Contribution to journalArticle

Kim, Hyongbum ; Choi, Ji Young ; Lee, Jung Min ; Park, Yoon Shin ; Suh, Hwal ; Song, Hae Ryong ; Jo, Sangmee Ahn ; Jo, Inho. / Dexamethasone increases angiopoietin-1 and quiescent hematopoietic stem cells : A novel mechanism of dexamethasone-induced hematoprotection. In: FEBS Letters. 2008 ; Vol. 582, No. 23-24. pp. 3509-3514.
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