Dextromethorphan modulates the AP-1 DNA-binding activity induced by kainic acid

Hyoung Chun Kim, Guoying Bing, Wang Kee Jhoo, Kwang Ho Ko, Won Ki Kim, Dong Chul Lee, Eun Jhoo Shin, Jau Shyong Hong

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

We have recently reported that dextromethorphan attenuates the neurotoxicity induced by kainic acid in a dose-related fashion. Pretreatments with dextromethorphan (50 mg/kg, p.o. X2) significantly reduced the activator protein-1 DNA-binding activity and the Fos-related antigen-immunoreactive protein induced by kainic acid (10 mg/kg, i.p.) in the CA1, but not the CA3 or the dentate gyms sector of the rat hippocampus. Paradoxically, dextromethorphan itself caused an elevated activator protein-1 DNA-binding activity and Fos-related antigen-immunoreactive protein in the CA1 region which lasted for at least 4 days. The results suggest that the CA1 area is the critical site for mediating the putative neuroprotective effect induced by dextromethorphan.

Original languageEnglish
Pages (from-to)125-132
Number of pages8
JournalBrain Research
Volume824
Issue number1
DOIs
Publication statusPublished - 1999 Apr 3

Keywords

  • Activator protein-1
  • Dextromethorphan
  • Fos-related antigen
  • Hippocampus
  • Kainic acid
  • Neuroprotection

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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    Kim, H. C., Bing, G., Jhoo, W. K., Ko, K. H., Kim, W. K., Lee, D. C., Shin, E. J., & Hong, J. S. (1999). Dextromethorphan modulates the AP-1 DNA-binding activity induced by kainic acid. Brain Research, 824(1), 125-132. https://doi.org/10.1016/S0006-8993(99)01155-5