Dextromethorphan modulates the AP-1 DNA-binding activity induced by kainic acid

Hyoung Chun Kim, Guoying Bing, Wang Kee Jhoo, Kwang Ho Ko, Won-Ki Kim, Dong Chul Lee, Eun Jhoo Shin, Jau Shyong Hong

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

We have recently reported that dextromethorphan attenuates the neurotoxicity induced by kainic acid in a dose-related fashion. Pretreatments with dextromethorphan (50 mg/kg, p.o. X2) significantly reduced the activator protein-1 DNA-binding activity and the Fos-related antigen-immunoreactive protein induced by kainic acid (10 mg/kg, i.p.) in the CA1, but not the CA3 or the dentate gyms sector of the rat hippocampus. Paradoxically, dextromethorphan itself caused an elevated activator protein-1 DNA-binding activity and Fos-related antigen-immunoreactive protein in the CA1 region which lasted for at least 4 days. The results suggest that the CA1 area is the critical site for mediating the putative neuroprotective effect induced by dextromethorphan.

Original languageEnglish
Pages (from-to)125-132
Number of pages8
JournalBrain Research
Volume824
Issue number1
DOIs
Publication statusPublished - 1999 Apr 3
Externally publishedYes

Fingerprint

Dextromethorphan
Kainic Acid
Transcription Factor AP-1
Proto-Oncogene Proteins c-fos
DNA
Neuroprotective Agents
Hippocampus
Proteins

Keywords

  • Activator protein-1
  • Dextromethorphan
  • Fos-related antigen
  • Hippocampus
  • Kainic acid
  • Neuroprotection

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kim, H. C., Bing, G., Jhoo, W. K., Ko, K. H., Kim, W-K., Lee, D. C., ... Hong, J. S. (1999). Dextromethorphan modulates the AP-1 DNA-binding activity induced by kainic acid. Brain Research, 824(1), 125-132. https://doi.org/10.1016/S0006-8993(99)01155-5

Dextromethorphan modulates the AP-1 DNA-binding activity induced by kainic acid. / Kim, Hyoung Chun; Bing, Guoying; Jhoo, Wang Kee; Ko, Kwang Ho; Kim, Won-Ki; Lee, Dong Chul; Shin, Eun Jhoo; Hong, Jau Shyong.

In: Brain Research, Vol. 824, No. 1, 03.04.1999, p. 125-132.

Research output: Contribution to journalArticle

Kim, HC, Bing, G, Jhoo, WK, Ko, KH, Kim, W-K, Lee, DC, Shin, EJ & Hong, JS 1999, 'Dextromethorphan modulates the AP-1 DNA-binding activity induced by kainic acid', Brain Research, vol. 824, no. 1, pp. 125-132. https://doi.org/10.1016/S0006-8993(99)01155-5
Kim, Hyoung Chun ; Bing, Guoying ; Jhoo, Wang Kee ; Ko, Kwang Ho ; Kim, Won-Ki ; Lee, Dong Chul ; Shin, Eun Jhoo ; Hong, Jau Shyong. / Dextromethorphan modulates the AP-1 DNA-binding activity induced by kainic acid. In: Brain Research. 1999 ; Vol. 824, No. 1. pp. 125-132.
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