Diagnosis and treatment of latent tuberculosis infection

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

A small number of viable tuberculosis bacilli can reside in an individual with latent tuberculosis infection (LTBI) without obvious clinical symptoms or abnormal chest radiographs. Diagnosis and treatment for LTBI are important for tuberculosis (TB) control in public and private health, especially in high-risk populations. The updated 2014 Korean guidelines for TB recommend that tuberculin skin tests, interferon-gamma release assays, or a combination of the two can be used for LTBI diagnosis according to age and immune status of the host as well as TB contact history. The regimens for LTBI treatment include isoniazid, rifampicin, or isoniazid/rifampicin. However, results of drug susceptibility test from the index case must be considered in selecting the appropriate drug for recent contacts. Standardized LTBI diagnosis and treatment based on the new 2014 guidelines will contribute to the effective TB control in Korea as well as to the establishment of updated guidelines.

Original languageEnglish
Pages (from-to)56-63
Number of pages8
JournalTuberculosis and Respiratory Diseases
Volume78
Issue number2
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Latent Tuberculosis
Tuberculosis
Isoniazid
Guidelines
Rifampin
Interferon-gamma Release Tests
Tuberculin Test
Korea
Skin Tests
Pharmaceutical Preparations
Bacillus
Thorax
Public Health
History
Population

Keywords

  • Interferon-gamma release assay
  • Latent tuberculosis
  • Tuberculin test

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Diagnosis and treatment of latent tuberculosis infection. / Lee, Seung Heon.

In: Tuberculosis and Respiratory Diseases, Vol. 78, No. 2, 01.01.2015, p. 56-63.

Research output: Contribution to journalReview article

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