Diagnosis of Alzheimer’s disease using view-aligned hypergraph learning with incomplete multi-modality data

Mingxia Liu, Jun Zhang, Pew Thian Yap, Dinggang Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Effectively utilizing incomplete multi-modality data for diagnosis of Alzheimer’s disease (AD) is still an area of active research. Several multi-view learning methods have recently been developed to deal with missing data,with each view corresponding to a specific modality or a combination of several modalities. However,existing methods usually ignore the underlying coherence among views,which may lead to suboptimal learning performance. In this paper,we propose a view-aligned hypergraph learning (VAHL) method to explicitly model the coherence among the views. Specifically,we first divide the original data into several views based on possible combinations of modalities,followed by a sparse representation based hypergraph construction process in each view. A view-aligned hypergraph classification (VAHC) model is then proposed,by using a view-aligned regularizer to model the view coherence. We further assemble the class probability scores generated from VAHC via a multi-view label fusion method to make a final classification decision. We evaluate our method on the baseline ADNI-1 database having 807 subjects and three modalities (i.e.,MRI,PET,and CSF). Our method achieves at least a 4.6% improvement in classification accuracy compared with state-of-the-art methods for AD/MCI diagnosis.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2016 - 19th International Conference, Proceedings
PublisherSpringer Verlag
Pages308-316
Number of pages9
Volume9900 LNCS
ISBN (Print)9783319467191
DOIs
Publication statusPublished - 2016
Externally publishedYes
Event1st International Workshop on Simulation and Synthesis in Medical Imaging, SASHIMI 2016 held in conjunction with 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016 - Athens, Greece
Duration: 2016 Oct 212016 Oct 21

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9900 LNCS
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other1st International Workshop on Simulation and Synthesis in Medical Imaging, SASHIMI 2016 held in conjunction with 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016
CountryGreece
CityAthens
Period16/10/2116/10/21

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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  • Cite this

    Liu, M., Zhang, J., Yap, P. T., & Shen, D. (2016). Diagnosis of Alzheimer’s disease using view-aligned hypergraph learning with incomplete multi-modality data. In Medical Image Computing and Computer-Assisted Intervention - MICCAI 2016 - 19th International Conference, Proceedings (Vol. 9900 LNCS, pp. 308-316). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 9900 LNCS). Springer Verlag. https://doi.org/10.1007/978-3-319-46720-7_36