Diagnosis of Helicobacter pylori infection

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Helicobacter pylori (H. pylori) infection can be diagnosed either by invasive techniques requiring endoscopy and biopsy (histological examination, culture, polymerase chain reaction) and or noninvasive techniques (urea breath test, serology, urine or blood, detection of H. pylori antigen in stool specimen). At present, no single test can be absolutely sufficient to detect the colonization by H. pylori, and a combination of above two tests is recommended if feasible. Because all the tests have their pitfalls and limitations, the choice of tests should depend on the clinical circumstances, the likelihood ratio of positive and negative tests, the cost-effectiveness of the testing strategy, and the availability of the tests. It is important to know which test in a certain clinical setting gives the best outcome. Some clinical circumstances warrant invasive studies, principally in patients with alarm symptoms (bleeding, weight loss, etc.) as well as older patients with new-onset dyspepsia. Endoscopy may also be advisable in patients who have failed eradication therapy and need culture to examine antimicrobial sensitivity testing to determine appropriate regimen. Recent Western studies have also demonstrated that a strategy of 'test and treat' for H. pylori in uninvestigated, young (<45 years), dyspeptic patients in primary care is safe and reduces the need for endoscopy. Therefore, it is necessary to hold a second consensus meeting for the diagnosis and treatment of H. pylori infection in Korea for the renewal of clinical guidelines in primary, secondary, and tertiary care based an evidence-based analysis.

Original languageEnglish
Pages (from-to)166-171
Number of pages6
JournalThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Volume46
Issue number3
Publication statusPublished - 2005 Jan 1

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Helicobacter Infections
Helicobacter pylori
Endoscopy
Primary Health Care
Secondary Care
Breath Tests
Dyspepsia
Serology
Tertiary Healthcare
Korea
Cost-Benefit Analysis
Urea
Weight Loss
Urine
Guidelines
Hemorrhage
Biopsy
Antigens
Polymerase Chain Reaction
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Diagnosis of Helicobacter pylori infection. / Lee, Sang Woo.

In: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, Vol. 46, No. 3, 01.01.2005, p. 166-171.

Research output: Contribution to journalReview article

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