Abstract
Objective: The purpose of this study was to compare the diagnostic performance of sialography and salivary ultrasonography (US) for Sjögren's syndrome (SS) patients. Methods: We searched Medline, Embase, and the Cochran library, and performed two meta-analyses on the diagnostic accuracy of sialography and salivary US in SS patients. Results: A total of six studies including 488 patients and 447 controls from two European and four Asian studies were available for the meta-analysis. The pooled sensitivity and specificity of sialography were 80.0% (95% confidence interval [CI] 76.4-83.2) and 89.0% (85.8-91.8), respectively, and 77.4 (73.7-80.9) and 81.5 (77.6-85.0) for US, respectively. For sialography, the PLR, NLR, and DOR were 9.296 (4.200-20.57), 0.228 (0.170-0.305), and 46.51 (16.14-134.0), respectively, and for US were 4.631 (2.707-7.864), 0.302 (0.226-0.403), and 17.48 (10.03-30.45), respectively. The area under the curve (AUC) of sialography was 0.824, and the Q* index was 0.757, while the AUC of US was 0.864, and its Q* index was 0.794, indicating that the diagnostic accuracy of US is comparable with sialography in SS patients. A subgroup meta-analysis according to the diagnostic criteria did not change the overall diagnostic accuracy. Conclusion: Our meta-analysis of published studies demonstrates that the diagnostic accuracy of salivary US is comparable with sialography in SS patients.
| Original language | English |
|---|---|
| Pages (from-to) | 516-522 |
| Number of pages | 7 |
| Journal | Clinical and Experimental Rheumatology |
| Volume | 32 |
| Issue number | 4 |
| Publication status | Published - 2014 Jan 1 |
Keywords
- Diagnostic accuracy
- Meta-analysis
- Sialography
- Sjögren's syndrome
- Ultrasonography
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology