Diagnostische Genauigkeit der 18F-FDG PET bzw. PET/CT für Vaskulitiden großer Gefäße: Eine Metaanalyse

Translated title of the contribution: Diagnostic accuracy of 18F-FDG PET or PET/CT for large vessel vasculitis: A meta-analysis

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective: The purpose of this study was to evaluate the diagnostic performance of 18F-fluorodeoxyglucose positron-emission tomography (18F-FDG PET) or positron-emission tomography/computed tomography (PET/CT) for patients with large vessel vasculitis. Methods: Based on a search in the PubMed, Embase, and Cochrane Library databases, a meta-analysis was performed on the diagnostic accuracy of 18F-FDG PET or PET/CT in patients with large vessel vasculitis. Results: A total of eight studies involving 400 subjects (170 vasculitis patients and 230 controls) were selected for meta-analysis. The pooled sensitivity and specificity of 18F-FDG PET or PET/CT were 75.9 % (95 % confidence interval, CI 68.7–82.1) and 93.0 % (95 % CI 88.9–96.0), respectively. The positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) were 7.267 (95 % CI 3.707–14.24), 0.303 (95 % CI 0.229–0.400), and 32.04 (95 % CI 13.08–78.45), respectively. The area under the curve (AUC) was 0.863 and the Q* index 0.794, indicating good diagnostic accuracy. There was no evidence of a threshold effect (Spearman’s correlation coefficient = 0.120, p = 0.776). When the data were limited to giant cell arteritis (GCA), the pooled sensitivity and specificity of 18F-FDG PET or PET/CT were 83.3 % (95 % CI 72.1–91.4) and 89.6 % (95 % CI 79.7–95.7), respectively; AUC was 0.884, and the Q* index 0.815, indicating modest accuracy with a small increase in diagnostic accuracy. Conclusion: This meta-analysis of published studies demonstrates that 18F-FDG PET or PET/CT has good diagnostic accuracy for large vessel vasculitis and plays an important role in the diagnosis of this condition.

Original languageGerman
Pages (from-to)924-931
Number of pages8
JournalZeitschrift fur Rheumatologie
Volume75
Issue number9
DOIs
Publication statusPublished - 2016 Nov 1

Fingerprint

Fluorodeoxyglucose F18
Vasculitis
Positron-Emission Tomography
Meta-Analysis
Area Under Curve
Sensitivity and Specificity
Giant Cell Arteritis
PubMed
Libraries
Odds Ratio
Positron Emission Tomography Computed Tomography
Databases
Confidence Intervals

Keywords

  • Giant cell arteritis
  • Imaging
  • Sensitivity
  • Specificity
  • Takayasu arteritis

ASJC Scopus subject areas

  • Rheumatology

Cite this

@article{dc9b42c02f1e474f9da7522578caf204,
title = "Diagnostische Genauigkeit der 18F-FDG PET bzw. PET/CT f{\"u}r Vaskulitiden gro{\ss}er Gef{\"a}{\ss}e: Eine Metaanalyse",
abstract = "Objective: The purpose of this study was to evaluate the diagnostic performance of 18F-fluorodeoxyglucose positron-emission tomography (18F-FDG PET) or positron-emission tomography/computed tomography (PET/CT) for patients with large vessel vasculitis. Methods: Based on a search in the PubMed, Embase, and Cochrane Library databases, a meta-analysis was performed on the diagnostic accuracy of 18F-FDG PET or PET/CT in patients with large vessel vasculitis. Results: A total of eight studies involving 400 subjects (170 vasculitis patients and 230 controls) were selected for meta-analysis. The pooled sensitivity and specificity of 18F-FDG PET or PET/CT were 75.9 {\%} (95 {\%} confidence interval, CI 68.7–82.1) and 93.0 {\%} (95 {\%} CI 88.9–96.0), respectively. The positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) were 7.267 (95 {\%} CI 3.707–14.24), 0.303 (95 {\%} CI 0.229–0.400), and 32.04 (95 {\%} CI 13.08–78.45), respectively. The area under the curve (AUC) was 0.863 and the Q* index 0.794, indicating good diagnostic accuracy. There was no evidence of a threshold effect (Spearman’s correlation coefficient = 0.120, p = 0.776). When the data were limited to giant cell arteritis (GCA), the pooled sensitivity and specificity of 18F-FDG PET or PET/CT were 83.3 {\%} (95 {\%} CI 72.1–91.4) and 89.6 {\%} (95 {\%} CI 79.7–95.7), respectively; AUC was 0.884, and the Q* index 0.815, indicating modest accuracy with a small increase in diagnostic accuracy. Conclusion: This meta-analysis of published studies demonstrates that 18F-FDG PET or PET/CT has good diagnostic accuracy for large vessel vasculitis and plays an important role in the diagnosis of this condition.",
keywords = "Giant cell arteritis, Imaging, Sensitivity, Specificity, Takayasu arteritis",
author = "Lee, {Young Ho} and Sungjae Choi and Ji, {Jong Dae} and Song, {Gwan Gyu}",
year = "2016",
month = "11",
day = "1",
doi = "10.1007/s00393-015-1674-2",
language = "German",
volume = "75",
pages = "924--931",
journal = "Zeitschrift fur Rheumatologie",
issn = "0340-1855",
publisher = "D. Steinkopff-Verlag",
number = "9",

}

TY - JOUR

T1 - Diagnostische Genauigkeit der 18F-FDG PET bzw. PET/CT für Vaskulitiden großer Gefäße

T2 - Eine Metaanalyse

AU - Lee, Young Ho

AU - Choi, Sungjae

AU - Ji, Jong Dae

AU - Song, Gwan Gyu

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Objective: The purpose of this study was to evaluate the diagnostic performance of 18F-fluorodeoxyglucose positron-emission tomography (18F-FDG PET) or positron-emission tomography/computed tomography (PET/CT) for patients with large vessel vasculitis. Methods: Based on a search in the PubMed, Embase, and Cochrane Library databases, a meta-analysis was performed on the diagnostic accuracy of 18F-FDG PET or PET/CT in patients with large vessel vasculitis. Results: A total of eight studies involving 400 subjects (170 vasculitis patients and 230 controls) were selected for meta-analysis. The pooled sensitivity and specificity of 18F-FDG PET or PET/CT were 75.9 % (95 % confidence interval, CI 68.7–82.1) and 93.0 % (95 % CI 88.9–96.0), respectively. The positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) were 7.267 (95 % CI 3.707–14.24), 0.303 (95 % CI 0.229–0.400), and 32.04 (95 % CI 13.08–78.45), respectively. The area under the curve (AUC) was 0.863 and the Q* index 0.794, indicating good diagnostic accuracy. There was no evidence of a threshold effect (Spearman’s correlation coefficient = 0.120, p = 0.776). When the data were limited to giant cell arteritis (GCA), the pooled sensitivity and specificity of 18F-FDG PET or PET/CT were 83.3 % (95 % CI 72.1–91.4) and 89.6 % (95 % CI 79.7–95.7), respectively; AUC was 0.884, and the Q* index 0.815, indicating modest accuracy with a small increase in diagnostic accuracy. Conclusion: This meta-analysis of published studies demonstrates that 18F-FDG PET or PET/CT has good diagnostic accuracy for large vessel vasculitis and plays an important role in the diagnosis of this condition.

AB - Objective: The purpose of this study was to evaluate the diagnostic performance of 18F-fluorodeoxyglucose positron-emission tomography (18F-FDG PET) or positron-emission tomography/computed tomography (PET/CT) for patients with large vessel vasculitis. Methods: Based on a search in the PubMed, Embase, and Cochrane Library databases, a meta-analysis was performed on the diagnostic accuracy of 18F-FDG PET or PET/CT in patients with large vessel vasculitis. Results: A total of eight studies involving 400 subjects (170 vasculitis patients and 230 controls) were selected for meta-analysis. The pooled sensitivity and specificity of 18F-FDG PET or PET/CT were 75.9 % (95 % confidence interval, CI 68.7–82.1) and 93.0 % (95 % CI 88.9–96.0), respectively. The positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) were 7.267 (95 % CI 3.707–14.24), 0.303 (95 % CI 0.229–0.400), and 32.04 (95 % CI 13.08–78.45), respectively. The area under the curve (AUC) was 0.863 and the Q* index 0.794, indicating good diagnostic accuracy. There was no evidence of a threshold effect (Spearman’s correlation coefficient = 0.120, p = 0.776). When the data were limited to giant cell arteritis (GCA), the pooled sensitivity and specificity of 18F-FDG PET or PET/CT were 83.3 % (95 % CI 72.1–91.4) and 89.6 % (95 % CI 79.7–95.7), respectively; AUC was 0.884, and the Q* index 0.815, indicating modest accuracy with a small increase in diagnostic accuracy. Conclusion: This meta-analysis of published studies demonstrates that 18F-FDG PET or PET/CT has good diagnostic accuracy for large vessel vasculitis and plays an important role in the diagnosis of this condition.

KW - Giant cell arteritis

KW - Imaging

KW - Sensitivity

KW - Specificity

KW - Takayasu arteritis

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U2 - 10.1007/s00393-015-1674-2

DO - 10.1007/s00393-015-1674-2

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JO - Zeitschrift fur Rheumatologie

JF - Zeitschrift fur Rheumatologie

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