Diagnostische Genauigkeit von Anti-MCV- und Anti-CCP-Antikörpern bei rheumatoider Arthritis

Eine Metaanalyse

Translated title of the contribution: Diagnostic accuracy of anti-MCV and anti-CCP antibodies in rheumatoid arthritis: A meta-analysis

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: The purpose of this study was to compare the diagnostic performance of anti-mutated citrullinated vimentin (anti-MCV) and anti-cyclic citrullinated peptide (anti-CCP) antibodies in rheumatoid arthritis (RA). Methods: We searched the Medline, Embase, and Cochrane library databases and performed two meta-analyses on the diagnostic accuracy of anti-MCV and anti-CCP in patients with RA compared to healthy controls. Results: We identified 12 studies that included a total of 2003 RA patients and 831 healthy controls for the meta-analysis. The pooled sensitivity and specificity of anti-MCV were 68.6 % [95 % confidence interval (CI) 66.6–79.7] and 94.2 % (95 % CI 92.4–96.7) and those of anti-CCP were 61.7 % (95 % CI 59.5–63.8) and 97.1 % (95 % CI 96.7–98.1), respectively. Anti-MCV PLR, NLR, and DOR were 12.99 (95 % CI 8.013–21.27), 0.297 (95 % CI 0.238–0.369), and 47.78 (95 % CI 28.59–79.84), and those for anti-CCP were 16.71 (95 % CI 11.42–24.47), 0.378 (95 % CI 0.325–0.439), and 54.20 (95 % CI 31.65–92.82), respectively. The AUC of anti-MCV was 0.886, and its Q* index was 0.817, indicating modest accuracy, while the AUC of anti-CCP was 0.946, and its Q* index was 0.885. The sensitivity of anti-MCV was significantly higher than that of anti-CCP in the diagnosis of RA (difference 0.069, 95 % CI 0.039–0.098, p < 0.0001), but the specificity of anti-MCV was lower than that of anti-CCP (difference − 0.029, 95 % CI − 0.051 to − 0.006, p = 0.012). The Q* index of anti-MCV was significantly lower than that of anti-CCP (difference − 0.068, 95 % CI − 0.070 to − 0.065, p < 0.0001). Conclusion: Our meta-analysis demonstrates that anti-MCV is more sensitive but less specific, and has lower diagnostic accuracy than anti-CCP in RA, although anti-MCV and anti-CCP showed comparable high PLRs.

Original languageGerman
Pages (from-to)911-918
Number of pages8
JournalZeitschrift fur Rheumatologie
Volume74
Issue number10
DOIs
Publication statusPublished - 2015 Dec 1

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Vimentin
Meta-Analysis
Rheumatoid Arthritis
Confidence Intervals
Antibodies
cyclic citrullinated peptide
Area Under Curve
Libraries
Databases

Keywords

  • Autoantibodies
  • Autoantigens
  • Autoimmune diseases
  • Biological marker
  • Early diagnosis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Diagnostische Genauigkeit von Anti-MCV- und Anti-CCP-Antikörpern bei rheumatoider Arthritis : Eine Metaanalyse. / Lee, Young Ho; Bae, S. C.; Song, Gwan Gyu.

In: Zeitschrift fur Rheumatologie, Vol. 74, No. 10, 01.12.2015, p. 911-918.

Research output: Contribution to journalArticle

@article{6665d59acf1f4e0a90b320f2c9ea0acf,
title = "Diagnostische Genauigkeit von Anti-MCV- und Anti-CCP-Antik{\"o}rpern bei rheumatoider Arthritis: Eine Metaanalyse",
abstract = "Objective: The purpose of this study was to compare the diagnostic performance of anti-mutated citrullinated vimentin (anti-MCV) and anti-cyclic citrullinated peptide (anti-CCP) antibodies in rheumatoid arthritis (RA). Methods: We searched the Medline, Embase, and Cochrane library databases and performed two meta-analyses on the diagnostic accuracy of anti-MCV and anti-CCP in patients with RA compared to healthy controls. Results: We identified 12 studies that included a total of 2003 RA patients and 831 healthy controls for the meta-analysis. The pooled sensitivity and specificity of anti-MCV were 68.6 {\%} [95 {\%} confidence interval (CI) 66.6–79.7] and 94.2 {\%} (95 {\%} CI 92.4–96.7) and those of anti-CCP were 61.7 {\%} (95 {\%} CI 59.5–63.8) and 97.1 {\%} (95 {\%} CI 96.7–98.1), respectively. Anti-MCV PLR, NLR, and DOR were 12.99 (95 {\%} CI 8.013–21.27), 0.297 (95 {\%} CI 0.238–0.369), and 47.78 (95 {\%} CI 28.59–79.84), and those for anti-CCP were 16.71 (95 {\%} CI 11.42–24.47), 0.378 (95 {\%} CI 0.325–0.439), and 54.20 (95 {\%} CI 31.65–92.82), respectively. The AUC of anti-MCV was 0.886, and its Q* index was 0.817, indicating modest accuracy, while the AUC of anti-CCP was 0.946, and its Q* index was 0.885. The sensitivity of anti-MCV was significantly higher than that of anti-CCP in the diagnosis of RA (difference 0.069, 95 {\%} CI 0.039–0.098, p < 0.0001), but the specificity of anti-MCV was lower than that of anti-CCP (difference − 0.029, 95 {\%} CI − 0.051 to − 0.006, p = 0.012). The Q* index of anti-MCV was significantly lower than that of anti-CCP (difference − 0.068, 95 {\%} CI − 0.070 to − 0.065, p < 0.0001). Conclusion: Our meta-analysis demonstrates that anti-MCV is more sensitive but less specific, and has lower diagnostic accuracy than anti-CCP in RA, although anti-MCV and anti-CCP showed comparable high PLRs.",
keywords = "Autoantibodies, Autoantigens, Autoimmune diseases, Biological marker, Early diagnosis",
author = "Lee, {Young Ho} and Bae, {S. C.} and Song, {Gwan Gyu}",
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T1 - Diagnostische Genauigkeit von Anti-MCV- und Anti-CCP-Antikörpern bei rheumatoider Arthritis

T2 - Eine Metaanalyse

AU - Lee, Young Ho

AU - Bae, S. C.

AU - Song, Gwan Gyu

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Objective: The purpose of this study was to compare the diagnostic performance of anti-mutated citrullinated vimentin (anti-MCV) and anti-cyclic citrullinated peptide (anti-CCP) antibodies in rheumatoid arthritis (RA). Methods: We searched the Medline, Embase, and Cochrane library databases and performed two meta-analyses on the diagnostic accuracy of anti-MCV and anti-CCP in patients with RA compared to healthy controls. Results: We identified 12 studies that included a total of 2003 RA patients and 831 healthy controls for the meta-analysis. The pooled sensitivity and specificity of anti-MCV were 68.6 % [95 % confidence interval (CI) 66.6–79.7] and 94.2 % (95 % CI 92.4–96.7) and those of anti-CCP were 61.7 % (95 % CI 59.5–63.8) and 97.1 % (95 % CI 96.7–98.1), respectively. Anti-MCV PLR, NLR, and DOR were 12.99 (95 % CI 8.013–21.27), 0.297 (95 % CI 0.238–0.369), and 47.78 (95 % CI 28.59–79.84), and those for anti-CCP were 16.71 (95 % CI 11.42–24.47), 0.378 (95 % CI 0.325–0.439), and 54.20 (95 % CI 31.65–92.82), respectively. The AUC of anti-MCV was 0.886, and its Q* index was 0.817, indicating modest accuracy, while the AUC of anti-CCP was 0.946, and its Q* index was 0.885. The sensitivity of anti-MCV was significantly higher than that of anti-CCP in the diagnosis of RA (difference 0.069, 95 % CI 0.039–0.098, p < 0.0001), but the specificity of anti-MCV was lower than that of anti-CCP (difference − 0.029, 95 % CI − 0.051 to − 0.006, p = 0.012). The Q* index of anti-MCV was significantly lower than that of anti-CCP (difference − 0.068, 95 % CI − 0.070 to − 0.065, p < 0.0001). Conclusion: Our meta-analysis demonstrates that anti-MCV is more sensitive but less specific, and has lower diagnostic accuracy than anti-CCP in RA, although anti-MCV and anti-CCP showed comparable high PLRs.

AB - Objective: The purpose of this study was to compare the diagnostic performance of anti-mutated citrullinated vimentin (anti-MCV) and anti-cyclic citrullinated peptide (anti-CCP) antibodies in rheumatoid arthritis (RA). Methods: We searched the Medline, Embase, and Cochrane library databases and performed two meta-analyses on the diagnostic accuracy of anti-MCV and anti-CCP in patients with RA compared to healthy controls. Results: We identified 12 studies that included a total of 2003 RA patients and 831 healthy controls for the meta-analysis. The pooled sensitivity and specificity of anti-MCV were 68.6 % [95 % confidence interval (CI) 66.6–79.7] and 94.2 % (95 % CI 92.4–96.7) and those of anti-CCP were 61.7 % (95 % CI 59.5–63.8) and 97.1 % (95 % CI 96.7–98.1), respectively. Anti-MCV PLR, NLR, and DOR were 12.99 (95 % CI 8.013–21.27), 0.297 (95 % CI 0.238–0.369), and 47.78 (95 % CI 28.59–79.84), and those for anti-CCP were 16.71 (95 % CI 11.42–24.47), 0.378 (95 % CI 0.325–0.439), and 54.20 (95 % CI 31.65–92.82), respectively. The AUC of anti-MCV was 0.886, and its Q* index was 0.817, indicating modest accuracy, while the AUC of anti-CCP was 0.946, and its Q* index was 0.885. The sensitivity of anti-MCV was significantly higher than that of anti-CCP in the diagnosis of RA (difference 0.069, 95 % CI 0.039–0.098, p < 0.0001), but the specificity of anti-MCV was lower than that of anti-CCP (difference − 0.029, 95 % CI − 0.051 to − 0.006, p = 0.012). The Q* index of anti-MCV was significantly lower than that of anti-CCP (difference − 0.068, 95 % CI − 0.070 to − 0.065, p < 0.0001). Conclusion: Our meta-analysis demonstrates that anti-MCV is more sensitive but less specific, and has lower diagnostic accuracy than anti-CCP in RA, although anti-MCV and anti-CCP showed comparable high PLRs.

KW - Autoantibodies

KW - Autoantigens

KW - Autoimmune diseases

KW - Biological marker

KW - Early diagnosis

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