Diagnostische Genauigkeit von Anti-Sa- und Anti-RA33-Antikörpern bei rheumatoider Arthritis: eine Metaanalyse

Translated title of the contribution: Diagnostic accuracy of anti-Sa and anti-RA33 antibodies in rheumatoid arthritis: a meta-analysis

Young Ho Lee, S. C. Bae

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: This study evaluated the diagnostic accuracy of anti-Sa and anti-RA33 antibodies in rheumatoid arthritis (RA). Methods: PubMed, Embase, and Cochrane library databases were searched for relevant studies, and 2 meta-analyses were performed to determine the diagnostic accuracy of anti-Sa and anti-RA33 antibodies in patients with RA. Results: The meta-analysis included 17 studies. Pooled sensitivity and specificity of anti-Sa antibody were 39.5 % (95 % confidence interval [CI] 36.5–42.4) and 96.8 % (95 % CI 95.9–97.4), respectively, and those of anti-RA33 antibody were 31.8 % (95 % CI 28.7–35.0) and 90.1 % (95 % CI 87.8–92.1), respectively. PLR, NLR, and DOR of anti-Sa antibody were 14.11 (95 % CI 7.076–28.13), 0.607 (95 % CI 0.558–0.703), and 22.76 (95 % C, 11.10–46.69), respectively, and those of anti-RA33 antibody were 3.429 (95 % CI 2.039–5.765), 0.761 (95 % CI 0.681–0.851), and 4.597 (95 % CI 2.602–8.121), respectively. AUC and Q* index for anti-Sa antibody were 0.558 and 0.543, respectively, while those for anti-RA33 antibody were 0.501 and 0.500, respectively. Conclusions: Our meta-analysis indicated that both anti-Sa and anti-RA33 antibodies were highly specific but not sensitive for diagnosing RA.

Original languageGerman
Pages (from-to)535-538
Number of pages4
JournalZeitschrift fur Rheumatologie
Volume76
Issue number6
DOIs
Publication statusPublished - 2017 Aug 1

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Anti-Idiotypic Antibodies
Rheumatoid Arthritis
Confidence Intervals
Meta-Analysis
PubMed
Libraries
Area Under Curve
Databases
Sensitivity and Specificity

Keywords

  • Anti-RA33 antibody
  • Anti-Sa antibody
  • Connective tissue diseases
  • Diagnostic accuracy
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Diagnostische Genauigkeit von Anti-Sa- und Anti-RA33-Antikörpern bei rheumatoider Arthritis : eine Metaanalyse. / Lee, Young Ho; Bae, S. C.

In: Zeitschrift fur Rheumatologie, Vol. 76, No. 6, 01.08.2017, p. 535-538.

Research output: Contribution to journalArticle

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title = "Diagnostische Genauigkeit von Anti-Sa- und Anti-RA33-Antik{\"o}rpern bei rheumatoider Arthritis: eine Metaanalyse",
abstract = "Objective: This study evaluated the diagnostic accuracy of anti-Sa and anti-RA33 antibodies in rheumatoid arthritis (RA). Methods: PubMed, Embase, and Cochrane library databases were searched for relevant studies, and 2 meta-analyses were performed to determine the diagnostic accuracy of anti-Sa and anti-RA33 antibodies in patients with RA. Results: The meta-analysis included 17 studies. Pooled sensitivity and specificity of anti-Sa antibody were 39.5 {\%} (95 {\%} confidence interval [CI] 36.5–42.4) and 96.8 {\%} (95 {\%} CI 95.9–97.4), respectively, and those of anti-RA33 antibody were 31.8 {\%} (95 {\%} CI 28.7–35.0) and 90.1 {\%} (95 {\%} CI 87.8–92.1), respectively. PLR, NLR, and DOR of anti-Sa antibody were 14.11 (95 {\%} CI 7.076–28.13), 0.607 (95 {\%} CI 0.558–0.703), and 22.76 (95 {\%} C, 11.10–46.69), respectively, and those of anti-RA33 antibody were 3.429 (95 {\%} CI 2.039–5.765), 0.761 (95 {\%} CI 0.681–0.851), and 4.597 (95 {\%} CI 2.602–8.121), respectively. AUC and Q* index for anti-Sa antibody were 0.558 and 0.543, respectively, while those for anti-RA33 antibody were 0.501 and 0.500, respectively. Conclusions: Our meta-analysis indicated that both anti-Sa and anti-RA33 antibodies were highly specific but not sensitive for diagnosing RA.",
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N2 - Objective: This study evaluated the diagnostic accuracy of anti-Sa and anti-RA33 antibodies in rheumatoid arthritis (RA). Methods: PubMed, Embase, and Cochrane library databases were searched for relevant studies, and 2 meta-analyses were performed to determine the diagnostic accuracy of anti-Sa and anti-RA33 antibodies in patients with RA. Results: The meta-analysis included 17 studies. Pooled sensitivity and specificity of anti-Sa antibody were 39.5 % (95 % confidence interval [CI] 36.5–42.4) and 96.8 % (95 % CI 95.9–97.4), respectively, and those of anti-RA33 antibody were 31.8 % (95 % CI 28.7–35.0) and 90.1 % (95 % CI 87.8–92.1), respectively. PLR, NLR, and DOR of anti-Sa antibody were 14.11 (95 % CI 7.076–28.13), 0.607 (95 % CI 0.558–0.703), and 22.76 (95 % C, 11.10–46.69), respectively, and those of anti-RA33 antibody were 3.429 (95 % CI 2.039–5.765), 0.761 (95 % CI 0.681–0.851), and 4.597 (95 % CI 2.602–8.121), respectively. AUC and Q* index for anti-Sa antibody were 0.558 and 0.543, respectively, while those for anti-RA33 antibody were 0.501 and 0.500, respectively. Conclusions: Our meta-analysis indicated that both anti-Sa and anti-RA33 antibodies were highly specific but not sensitive for diagnosing RA.

AB - Objective: This study evaluated the diagnostic accuracy of anti-Sa and anti-RA33 antibodies in rheumatoid arthritis (RA). Methods: PubMed, Embase, and Cochrane library databases were searched for relevant studies, and 2 meta-analyses were performed to determine the diagnostic accuracy of anti-Sa and anti-RA33 antibodies in patients with RA. Results: The meta-analysis included 17 studies. Pooled sensitivity and specificity of anti-Sa antibody were 39.5 % (95 % confidence interval [CI] 36.5–42.4) and 96.8 % (95 % CI 95.9–97.4), respectively, and those of anti-RA33 antibody were 31.8 % (95 % CI 28.7–35.0) and 90.1 % (95 % CI 87.8–92.1), respectively. PLR, NLR, and DOR of anti-Sa antibody were 14.11 (95 % CI 7.076–28.13), 0.607 (95 % CI 0.558–0.703), and 22.76 (95 % C, 11.10–46.69), respectively, and those of anti-RA33 antibody were 3.429 (95 % CI 2.039–5.765), 0.761 (95 % CI 0.681–0.851), and 4.597 (95 % CI 2.602–8.121), respectively. AUC and Q* index for anti-Sa antibody were 0.558 and 0.543, respectively, while those for anti-RA33 antibody were 0.501 and 0.500, respectively. Conclusions: Our meta-analysis indicated that both anti-Sa and anti-RA33 antibodies were highly specific but not sensitive for diagnosing RA.

KW - Anti-RA33 antibody

KW - Anti-Sa antibody

KW - Connective tissue diseases

KW - Diagnostic accuracy

KW - Rheumatoid arthritis

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