Diagnostic and prognostic value of bone marrow angiogenesis and megakaryocyte c-Mpl expression in essential thrombocythemia

Ruben A. Mesa, Curtis A. Hanson, Chin Yang Li, Soo-Young Yoon, S. Vincent Rajkumar, Georgene Schroeder, Ayalew Tefferi

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The lack of diagnostic certainty in some patients makes it difficult to distinguish between primary and secondary forms of thrombocytosis. To augment current diagnostic studies for thrombocytosis, we retrospectively evaluated clinical records and bone marrow trephine specimens of 183 patients with thrombocytosis - 164 with essential thrombocythemia (ET), 19 with reactive thrombocytosis (RT) - for bone marrow angiogenesis, bone marrow megakaryocyte c-Mpl staining, and morphologic evidence of megakaryocyte proliferation. Angiogenesis was increased in patients with ET compared with healthy controls (P < .0001) and patients with RT (P = .006). In addition, an increase in angiogenesis was associated with certain disease features such as splenomegaly (P = .004) and reticulin fibrosis (P = .005). Decreased megakaryocyte c-Mpl staining was observed in a heterogeneous pattern in ET compared with healthy controls (P < .0001) and RT (P < .0001). Histologic stratifying criteria incorporating increased angiogenesis, decreased megakaryocyte c-Mpl expression, and marked megakaryocyte proliferation in the bone marrow was highly sensitive (97%) and specific (95%) for distinguishing ET from RT (P < .0001). However, with the current duration of follow-up available on the patients, none of the histologic features evaluated have yet demonstrated prognostic value for subsequent clinical course, vascular events, or survival.

Original languageEnglish
Pages (from-to)4131-4137
Number of pages7
JournalBlood
Volume99
Issue number11
DOIs
Publication statusPublished - 2002 Jun 1
Externally publishedYes

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Essential Thrombocythemia
Thrombocytosis
Megakaryocytes
Bone
Bone Marrow
Reticulin
Staining and Labeling
Splenomegaly
Blood Vessels
Fibrosis
Survival

ASJC Scopus subject areas

  • Hematology

Cite this

Mesa, R. A., Hanson, C. A., Li, C. Y., Yoon, S-Y., Vincent Rajkumar, S., Schroeder, G., & Tefferi, A. (2002). Diagnostic and prognostic value of bone marrow angiogenesis and megakaryocyte c-Mpl expression in essential thrombocythemia. Blood, 99(11), 4131-4137. https://doi.org/10.1182/blood.V99.11.4131

Diagnostic and prognostic value of bone marrow angiogenesis and megakaryocyte c-Mpl expression in essential thrombocythemia. / Mesa, Ruben A.; Hanson, Curtis A.; Li, Chin Yang; Yoon, Soo-Young; Vincent Rajkumar, S.; Schroeder, Georgene; Tefferi, Ayalew.

In: Blood, Vol. 99, No. 11, 01.06.2002, p. 4131-4137.

Research output: Contribution to journalArticle

Mesa, RA, Hanson, CA, Li, CY, Yoon, S-Y, Vincent Rajkumar, S, Schroeder, G & Tefferi, A 2002, 'Diagnostic and prognostic value of bone marrow angiogenesis and megakaryocyte c-Mpl expression in essential thrombocythemia', Blood, vol. 99, no. 11, pp. 4131-4137. https://doi.org/10.1182/blood.V99.11.4131
Mesa, Ruben A. ; Hanson, Curtis A. ; Li, Chin Yang ; Yoon, Soo-Young ; Vincent Rajkumar, S. ; Schroeder, Georgene ; Tefferi, Ayalew. / Diagnostic and prognostic value of bone marrow angiogenesis and megakaryocyte c-Mpl expression in essential thrombocythemia. In: Blood. 2002 ; Vol. 99, No. 11. pp. 4131-4137.
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