Diagnostic delay in inflammatory bowel disease increases the risk of intestinal surgery

Dong Won Lee, Ja Seol Koo, Jung Wan Choe, Sang Jun Suh, Seung Young Kim, Jong Jin Hyun, Sung Woo Jung, Young Kul Jung, Hyung Joon Yim, Sang Woo Lee

    Research output: Contribution to journalArticlepeer-review

    25 Citations (Scopus)

    Abstract

    AIM To investigate the factors affecting diagnostic delay and outcomes of diagnostic delay in inflammatory bowel disease (IBD) METHODS We retrospectively studied 165 patients with Crohn's disease (CD) and 130 patients with ulcerative colitis (UC) who were diagnosed and had follow up durations > 6 mo at Korea University Ansan Hospital from January 2000 to December 2015. A diagnostic delay was defined as the time interval between the first symptom onset and IBD diagnosis in which the 76th to 100th percentiles of patients were diagnosed. RESULTS The median diagnostic time interval was 6.2 and 2.4 mo in the patients with CD and UC, respectively. Among the initial symptoms, perianal discomfort before diagnosis (OR = 10.2, 95%CI: 1.93-54.3, P = 0.006) was associated with diagnostic delays in patients with CD; however, no clinical factor was associated with diagnostic delays in patients with UC. Diagnostic delays, stricturing type, and penetrating type were associated with increased intestinal surgery risks in CD (OR = 2.54, 95%CI: 1.06-6.09; OR = 4.44, 95%CI: 1.67-11.8; OR = 3.79, 95%CI: 1.14-12.6, respectively). In UC, a diagnostic delay was the only factor associated increased intestinal surgery risks (OR = 6.81, 95%CI: 1.12-41.4). CONCLUSION A diagnostic delay was associated with poor outcomes, such as increased intestinal surgery risks in patients with CD and UC.

    Original languageEnglish
    Pages (from-to)6474-6481
    Number of pages8
    JournalWorld journal of gastroenterology
    Volume23
    Issue number35
    DOIs
    Publication statusPublished - 2017 Sep 21

    Keywords

    • Crohn's disease
    • Diagnostic delay
    • Inflammatory bowel disease
    • Intestinal surgery
    • Ulcerative colitis

    ASJC Scopus subject areas

    • Gastroenterology

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