TY - JOUR
T1 - Diagnostic Performance of the Prostate Cancer Antigen 3 Test in Prostate Cancer
T2 - Systematic Review and Meta-analysis
AU - Lee, Donghyun
AU - Shim, Sung Ryul
AU - Ahn, Sun Tae
AU - Oh, Mi Mi
AU - Moon, Du Geon
AU - Park, Hong Seok
AU - Cheon, Jun
AU - Kim, Jong Wook
N1 - Funding Information:
This research was supported by Korea University , Grant number K1924991 . The authors have stated that they have no conflict of interest.
Publisher Copyright:
© 2020 The Author(s)
PY - 2020/10
Y1 - 2020/10
N2 - Purpose: To explore the diagnostic accuracy of prostate cancer antigen 3 (PCA3) test for the diagnosis of prostate cancer in this systematic review and meta-analysis. Patients and Methods: A systematic literature search of Medline, Embase, and Cochrane Library databases up to October 2019 was performed. The sensitivity, specificity, and diagnostic odds ratio with 95% confidence intervals (CIs) were calculated. The summary receiver operator characteristic graph came from individual studies. We also conducted metaregression analysis to identify the moderated factors. Results: Across 54 studies (17,575 patients), the pooled sensitivity, specificity, and diagnostic odds ratio of PCA3 were 0.71 (95% CI, 0.67-0.74), 0.68 (95% CI, 0.63-0.74), and 5.28 (95% CI, 4.28-6.51), respectively. The area under the summary receiver operator characteristic curve was 0.75 (95% CI, 0.71-0.79). Conclusion: Pooled data indicated that the PCA3 test had moderate sensitivity and specificity in the diagnosis of prostate cancer. PCA3 could be used as a noninvasive method for the diagnosis of prostate cancer. The purpose of this study was to assess the diagnostic accuracy of prostate cancer antigen 3 (PCA3) test for the diagnosis of prostate cancer through a systematic review and meta-analysis of 54 studies. Urinary PCA3 with a cutoff score of 35 had 71% pooled sensitivity and 68% pooled specificity. Urinary PCA3 is a noninvasive biomarker that can be used to aid in the diagnosis of prostate cancer.
AB - Purpose: To explore the diagnostic accuracy of prostate cancer antigen 3 (PCA3) test for the diagnosis of prostate cancer in this systematic review and meta-analysis. Patients and Methods: A systematic literature search of Medline, Embase, and Cochrane Library databases up to October 2019 was performed. The sensitivity, specificity, and diagnostic odds ratio with 95% confidence intervals (CIs) were calculated. The summary receiver operator characteristic graph came from individual studies. We also conducted metaregression analysis to identify the moderated factors. Results: Across 54 studies (17,575 patients), the pooled sensitivity, specificity, and diagnostic odds ratio of PCA3 were 0.71 (95% CI, 0.67-0.74), 0.68 (95% CI, 0.63-0.74), and 5.28 (95% CI, 4.28-6.51), respectively. The area under the summary receiver operator characteristic curve was 0.75 (95% CI, 0.71-0.79). Conclusion: Pooled data indicated that the PCA3 test had moderate sensitivity and specificity in the diagnosis of prostate cancer. PCA3 could be used as a noninvasive method for the diagnosis of prostate cancer. The purpose of this study was to assess the diagnostic accuracy of prostate cancer antigen 3 (PCA3) test for the diagnosis of prostate cancer through a systematic review and meta-analysis of 54 studies. Urinary PCA3 with a cutoff score of 35 had 71% pooled sensitivity and 68% pooled specificity. Urinary PCA3 is a noninvasive biomarker that can be used to aid in the diagnosis of prostate cancer.
KW - Diagnosis
KW - Meta-analysis
KW - Prostate cancer antigen 3
KW - Prostate-specific antigen
KW - Prostatic neoplasms
UR - http://www.scopus.com/inward/record.url?scp=85082936706&partnerID=8YFLogxK
U2 - 10.1016/j.clgc.2020.03.005
DO - 10.1016/j.clgc.2020.03.005
M3 - Article
AN - SCOPUS:85082936706
VL - 18
SP - 402-408.e5
JO - Clinical Genitourinary Cancer
JF - Clinical Genitourinary Cancer
SN - 1558-7673
IS - 5
ER -
