Diallyl disulfide (DADS) boosts TRAIL-Mediated apoptosis in colorectal cancer cells by inhibiting Bcl-2

Hong Jun Kim, Sanghee Kang, Dae Yeoung Kim, Sanguan You, Daeho Park, Sang Cheul Oh, Dae Hee Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Ever since several targeted agents were introduced a decade ago, progress in new therapeutic strategies for colorectal cancer (CRC) has been much slower than that for other cancers. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is widely known to induce cellular apoptosis in numerous cancer cell types. However, many cancer cells are resistant to the effects of TRAIL, and thus, approaches are needed to overcome TRAIL resistance. We demonstrated that non-cytotoxic doses of diallyl disulfide (DADS) increased TRAIL-associated cell death in CRC cell lines. Additionally, synergistic effects between DADS and TRAIL were validated in vivo in nude mice. One process involved in these effects includes down-regulation of the anti-apoptotic protein Bcl-2, and the synergistic effect of DADS with TRAIL was attenuated in Bcl-2-over-expressing cells. Taken together, the results of this study give new insights into the role of DADS in TRAIL-related repression of CRC progression by inhibition of Bcl-2.

Original languageEnglish
Pages (from-to)354-360
Number of pages7
JournalFood and Chemical Toxicology
Volume125
DOIs
Publication statusPublished - 2019 Mar 1

Fingerprint

colorectal neoplasms
Colorectal Neoplasms
apoptosis
Cells
Apoptosis
Neoplasms
Apoptosis Regulatory Proteins
tumor necrosis factors
Cell death
Nude Mice
cell death
Cell Death
Down-Regulation
Tumor Necrosis Factor-alpha
cell lines
Ligands
Cell Line
therapeutics
neoplasms
diallyl disulfide

Keywords

  • Bcl-2
  • Death receptor 5
  • Diallyl disulphide
  • TRAIL-Resistance

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Diallyl disulfide (DADS) boosts TRAIL-Mediated apoptosis in colorectal cancer cells by inhibiting Bcl-2. / Kim, Hong Jun; Kang, Sanghee; Kim, Dae Yeoung; You, Sanguan; Park, Daeho; Oh, Sang Cheul; Lee, Dae Hee.

In: Food and Chemical Toxicology, Vol. 125, 01.03.2019, p. 354-360.

Research output: Contribution to journalArticle

Kim, Hong Jun ; Kang, Sanghee ; Kim, Dae Yeoung ; You, Sanguan ; Park, Daeho ; Oh, Sang Cheul ; Lee, Dae Hee. / Diallyl disulfide (DADS) boosts TRAIL-Mediated apoptosis in colorectal cancer cells by inhibiting Bcl-2. In: Food and Chemical Toxicology. 2019 ; Vol. 125. pp. 354-360.
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