Dielectrophoretic technique for measurement of chemical and biological interactions

Hyun Baek Sang, Woo Jin Chang, Ju Yeoul Baek, Dae Sung Yoon, Rashid Bashir, Woo Lee Sang

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We present a novel dielectrophoretic technique that can be used to characterize molecular interactions inside a microfluidic device. Our approach allows functionalized beads which are initially at rest on a functionalized surface to be pulled away from the surface by the dielectrophoretic force acting on the beads. As a result, the interaction between the molecules on the surface and the beads can be quantitatively examined. We report detailed experimental results and validate the results with a model to show that the technique can be used to measure forces of interaction between molecules under various experimental conditions.

Original languageEnglish
Pages (from-to)7737-7742
Number of pages6
JournalAnalytical chemistry
Volume81
Issue number18
DOIs
Publication statusPublished - 2009 Sep 15
Externally publishedYes

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Molecules
Molecular interactions
Microfluidics

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Dielectrophoretic technique for measurement of chemical and biological interactions. / Sang, Hyun Baek; Chang, Woo Jin; Baek, Ju Yeoul; Yoon, Dae Sung; Bashir, Rashid; Sang, Woo Lee.

In: Analytical chemistry, Vol. 81, No. 18, 15.09.2009, p. 7737-7742.

Research output: Contribution to journalArticle

Sang, Hyun Baek ; Chang, Woo Jin ; Baek, Ju Yeoul ; Yoon, Dae Sung ; Bashir, Rashid ; Sang, Woo Lee. / Dielectrophoretic technique for measurement of chemical and biological interactions. In: Analytical chemistry. 2009 ; Vol. 81, No. 18. pp. 7737-7742.
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