Dietary fat and fiber intakes are not associated with patterns of urinary estrogen metabolites in premenopausal women

Hannah Oh, Stephanie A. Smith-Warner, Rulla M. Tamimi, Molin Wang, Xia Xu, Susan E. Hankinson, Barbara J. Fuhrman, Regina G. Ziegler, A. Heather Eliassen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Interindividual differences in the bioavailability of potentially carcinogenic estrogen and estrogen metabolites (EMs) may play a role in the risk of breast cancer. Objective: We examined whether dietary intakes of fiber and fat influence premenopausal EM profiles through effects on estrogen synthesis, metabolism, or excretion. Methods: We conducted a cross-sectional analysis of 598 premenopausal women who participated in a reproducibility study (n = 109) or served as controls in a nested case-control study of breast cancer (n = 489) within the Nurses' Health Study II. Dietary intakes of fiber and fat were assessed via semiquantitative food frequency questionnaires in 1995 and 1999. Midluteal urine samples were collected between 1996 and 1999 and EMs were quantified with the use of HPLC-tandem mass spectrometry. Linear mixed models were used to estimate creatinine-adjusted geometric means for individual EMs and their pathway groups across categories of dietary intake while controlling for total energy intake and potential confounders. Results: Higher total dietary fiber intake (>25 g/d vs. ≤15 g/d) was associated with significantly higher concentrations of 4-methoxyestradiol (50% difference, P-difference = 0.01, P-trend = 0.004) and lower concentrations of 17-epiestriol (-27% difference, P-difference = 0.03, P-trend = 0.03), but was not associated with any other EMs. The associations did not vary by fiber intake from different sources. Total fat intake (>35% energy vs. ≤25% energy) was suggestively positively associated with 17-epiestriol (22.6% difference, P-difference = 0.14, P-trend = 0.06); the association was significant for polyunsaturated fatty acid (37% difference, P-difference = 0.01, P-trend = 0.01) and trans fat (36.1% difference, P-difference = 0.01, P-trend = 0.01) intakes. Conclusion: Fiber and fat intakes were not strongly associated with patterns of estrogen metabolism in premenopausal women. Our data suggest estrogen metabolism is not a major mechanism through which dietary fiber and fat may affect breast or other hormone-related cancer risks.

Original languageEnglish
Pages (from-to)2109-2116
Number of pages8
JournalJournal of Nutrition
Volume145
Issue number9
DOIs
Publication statusPublished - 2015 Jan 1
Externally publishedYes

Fingerprint

Dietary Fats
Dietary Fiber
Estrogens
Estriol
Fats
Breast Neoplasms
Tandem Mass Spectrometry
Energy Intake
Unsaturated Fatty Acids
Biological Availability
Case-Control Studies
Linear Models
Creatinine
Breast
Cross-Sectional Studies
Nurses
High Pressure Liquid Chromatography
Urine
Hormones
Food

Keywords

  • Diet
  • Estrogen
  • Estrogen metabolites
  • Fat
  • Fiber
  • Premenopausal

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Oh, H., Smith-Warner, S. A., Tamimi, R. M., Wang, M., Xu, X., Hankinson, S. E., ... Eliassen, A. H. (2015). Dietary fat and fiber intakes are not associated with patterns of urinary estrogen metabolites in premenopausal women. Journal of Nutrition, 145(9), 2109-2116. https://doi.org/10.3945/jn.115.212779

Dietary fat and fiber intakes are not associated with patterns of urinary estrogen metabolites in premenopausal women. / Oh, Hannah; Smith-Warner, Stephanie A.; Tamimi, Rulla M.; Wang, Molin; Xu, Xia; Hankinson, Susan E.; Fuhrman, Barbara J.; Ziegler, Regina G.; Eliassen, A. Heather.

In: Journal of Nutrition, Vol. 145, No. 9, 01.01.2015, p. 2109-2116.

Research output: Contribution to journalArticle

Oh, H, Smith-Warner, SA, Tamimi, RM, Wang, M, Xu, X, Hankinson, SE, Fuhrman, BJ, Ziegler, RG & Eliassen, AH 2015, 'Dietary fat and fiber intakes are not associated with patterns of urinary estrogen metabolites in premenopausal women', Journal of Nutrition, vol. 145, no. 9, pp. 2109-2116. https://doi.org/10.3945/jn.115.212779
Oh, Hannah ; Smith-Warner, Stephanie A. ; Tamimi, Rulla M. ; Wang, Molin ; Xu, Xia ; Hankinson, Susan E. ; Fuhrman, Barbara J. ; Ziegler, Regina G. ; Eliassen, A. Heather. / Dietary fat and fiber intakes are not associated with patterns of urinary estrogen metabolites in premenopausal women. In: Journal of Nutrition. 2015 ; Vol. 145, No. 9. pp. 2109-2116.
@article{6a80afbbc8504a80af7055eb89efcfea,
title = "Dietary fat and fiber intakes are not associated with patterns of urinary estrogen metabolites in premenopausal women",
abstract = "Background: Interindividual differences in the bioavailability of potentially carcinogenic estrogen and estrogen metabolites (EMs) may play a role in the risk of breast cancer. Objective: We examined whether dietary intakes of fiber and fat influence premenopausal EM profiles through effects on estrogen synthesis, metabolism, or excretion. Methods: We conducted a cross-sectional analysis of 598 premenopausal women who participated in a reproducibility study (n = 109) or served as controls in a nested case-control study of breast cancer (n = 489) within the Nurses' Health Study II. Dietary intakes of fiber and fat were assessed via semiquantitative food frequency questionnaires in 1995 and 1999. Midluteal urine samples were collected between 1996 and 1999 and EMs were quantified with the use of HPLC-tandem mass spectrometry. Linear mixed models were used to estimate creatinine-adjusted geometric means for individual EMs and their pathway groups across categories of dietary intake while controlling for total energy intake and potential confounders. Results: Higher total dietary fiber intake (>25 g/d vs. ≤15 g/d) was associated with significantly higher concentrations of 4-methoxyestradiol (50{\%} difference, P-difference = 0.01, P-trend = 0.004) and lower concentrations of 17-epiestriol (-27{\%} difference, P-difference = 0.03, P-trend = 0.03), but was not associated with any other EMs. The associations did not vary by fiber intake from different sources. Total fat intake (>35{\%} energy vs. ≤25{\%} energy) was suggestively positively associated with 17-epiestriol (22.6{\%} difference, P-difference = 0.14, P-trend = 0.06); the association was significant for polyunsaturated fatty acid (37{\%} difference, P-difference = 0.01, P-trend = 0.01) and trans fat (36.1{\%} difference, P-difference = 0.01, P-trend = 0.01) intakes. Conclusion: Fiber and fat intakes were not strongly associated with patterns of estrogen metabolism in premenopausal women. Our data suggest estrogen metabolism is not a major mechanism through which dietary fiber and fat may affect breast or other hormone-related cancer risks.",
keywords = "Diet, Estrogen, Estrogen metabolites, Fat, Fiber, Premenopausal",
author = "Hannah Oh and Smith-Warner, {Stephanie A.} and Tamimi, {Rulla M.} and Molin Wang and Xia Xu and Hankinson, {Susan E.} and Fuhrman, {Barbara J.} and Ziegler, {Regina G.} and Eliassen, {A. Heather}",
year = "2015",
month = "1",
day = "1",
doi = "10.3945/jn.115.212779",
language = "English",
volume = "145",
pages = "2109--2116",
journal = "Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "9",

}

TY - JOUR

T1 - Dietary fat and fiber intakes are not associated with patterns of urinary estrogen metabolites in premenopausal women

AU - Oh, Hannah

AU - Smith-Warner, Stephanie A.

AU - Tamimi, Rulla M.

AU - Wang, Molin

AU - Xu, Xia

AU - Hankinson, Susan E.

AU - Fuhrman, Barbara J.

AU - Ziegler, Regina G.

AU - Eliassen, A. Heather

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background: Interindividual differences in the bioavailability of potentially carcinogenic estrogen and estrogen metabolites (EMs) may play a role in the risk of breast cancer. Objective: We examined whether dietary intakes of fiber and fat influence premenopausal EM profiles through effects on estrogen synthesis, metabolism, or excretion. Methods: We conducted a cross-sectional analysis of 598 premenopausal women who participated in a reproducibility study (n = 109) or served as controls in a nested case-control study of breast cancer (n = 489) within the Nurses' Health Study II. Dietary intakes of fiber and fat were assessed via semiquantitative food frequency questionnaires in 1995 and 1999. Midluteal urine samples were collected between 1996 and 1999 and EMs were quantified with the use of HPLC-tandem mass spectrometry. Linear mixed models were used to estimate creatinine-adjusted geometric means for individual EMs and their pathway groups across categories of dietary intake while controlling for total energy intake and potential confounders. Results: Higher total dietary fiber intake (>25 g/d vs. ≤15 g/d) was associated with significantly higher concentrations of 4-methoxyestradiol (50% difference, P-difference = 0.01, P-trend = 0.004) and lower concentrations of 17-epiestriol (-27% difference, P-difference = 0.03, P-trend = 0.03), but was not associated with any other EMs. The associations did not vary by fiber intake from different sources. Total fat intake (>35% energy vs. ≤25% energy) was suggestively positively associated with 17-epiestriol (22.6% difference, P-difference = 0.14, P-trend = 0.06); the association was significant for polyunsaturated fatty acid (37% difference, P-difference = 0.01, P-trend = 0.01) and trans fat (36.1% difference, P-difference = 0.01, P-trend = 0.01) intakes. Conclusion: Fiber and fat intakes were not strongly associated with patterns of estrogen metabolism in premenopausal women. Our data suggest estrogen metabolism is not a major mechanism through which dietary fiber and fat may affect breast or other hormone-related cancer risks.

AB - Background: Interindividual differences in the bioavailability of potentially carcinogenic estrogen and estrogen metabolites (EMs) may play a role in the risk of breast cancer. Objective: We examined whether dietary intakes of fiber and fat influence premenopausal EM profiles through effects on estrogen synthesis, metabolism, or excretion. Methods: We conducted a cross-sectional analysis of 598 premenopausal women who participated in a reproducibility study (n = 109) or served as controls in a nested case-control study of breast cancer (n = 489) within the Nurses' Health Study II. Dietary intakes of fiber and fat were assessed via semiquantitative food frequency questionnaires in 1995 and 1999. Midluteal urine samples were collected between 1996 and 1999 and EMs were quantified with the use of HPLC-tandem mass spectrometry. Linear mixed models were used to estimate creatinine-adjusted geometric means for individual EMs and their pathway groups across categories of dietary intake while controlling for total energy intake and potential confounders. Results: Higher total dietary fiber intake (>25 g/d vs. ≤15 g/d) was associated with significantly higher concentrations of 4-methoxyestradiol (50% difference, P-difference = 0.01, P-trend = 0.004) and lower concentrations of 17-epiestriol (-27% difference, P-difference = 0.03, P-trend = 0.03), but was not associated with any other EMs. The associations did not vary by fiber intake from different sources. Total fat intake (>35% energy vs. ≤25% energy) was suggestively positively associated with 17-epiestriol (22.6% difference, P-difference = 0.14, P-trend = 0.06); the association was significant for polyunsaturated fatty acid (37% difference, P-difference = 0.01, P-trend = 0.01) and trans fat (36.1% difference, P-difference = 0.01, P-trend = 0.01) intakes. Conclusion: Fiber and fat intakes were not strongly associated with patterns of estrogen metabolism in premenopausal women. Our data suggest estrogen metabolism is not a major mechanism through which dietary fiber and fat may affect breast or other hormone-related cancer risks.

KW - Diet

KW - Estrogen

KW - Estrogen metabolites

KW - Fat

KW - Fiber

KW - Premenopausal

UR - http://www.scopus.com/inward/record.url?scp=84941065498&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941065498&partnerID=8YFLogxK

U2 - 10.3945/jn.115.212779

DO - 10.3945/jn.115.212779

M3 - Article

VL - 145

SP - 2109

EP - 2116

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 9

ER -