Dietary nanosized Lactobacillus plantarum enhances the anticancer effect of kimchi on azoxymethane and dextran sulfate sodium-induced colon cancer in C57BL/6J mice

Hyun Ah Lee, Hyunung Kim, Kwang Won Lee, Kun Young Park

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4 Citations (Scopus)

Abstract

This study was undertaken to evaluate enhancement of the chemopreventive properties of kimchi by dietary nanosized Lactobacillus (Lab.) plantarum (nLp) in an azoxymethane (AOM)/dextran sulfate sodium (DSS)– induced colitis-associated colorectal cancer C57BL/6J mouse model. nLp is a dead, shrunken, processed form of Lab. plantarum isolated from kimchi that is 0.5–1.0 μm in size. The results obtained showed that animals fed kimchi with nLp (K-nLp) had longer colons and lower colon weights/length ratios and developed fewer tumors than mice fed kimchi alone (K). In addition, K-nLp administration reduced levels of proinflammatory cytokine serum levels and mediated the mRNA and protein expressions of inflammatory, apoptotic, and cell-cycle markers to suppress inflammation and induce tumor-cell apoptosis and cell-cycle arrest. Moreover, it elevated natural killer-cell cytotoxicity. The study suggests adding nLp to kimchi could improve the suppressive effect of kimchi on AOM/DSS-induced colorectal cancer. These findings indicate nLp has potential use as a functional chemopreventive ingredient in the food industry.

Original languageEnglish
Pages (from-to)147-159
Number of pages13
JournalJournal of Environmental Pathology, Toxicology and Oncology
Volume35
Issue number2
DOIs
Publication statusPublished - 2016

Fingerprint

Azoxymethane
Lactobacillus plantarum
Dextran Sulfate
Inbred C57BL Mouse
Colonic Neoplasms
Tumors
Colorectal Neoplasms
Colon
Cells
Food Industry
Colitis
Cytotoxicity
Cell Cycle Checkpoints
Natural Killer Cells
Neoplasms
Cell Cycle
Animals
Apoptosis
Cytokines
Inflammation

Keywords

  • C57BL/6J mouse
  • Colitis-associated colorectal cancer
  • Dietary nanosized lactobacillus plantarum
  • Kimchi

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Pathology and Forensic Medicine
  • Toxicology

Cite this

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title = "Dietary nanosized Lactobacillus plantarum enhances the anticancer effect of kimchi on azoxymethane and dextran sulfate sodium-induced colon cancer in C57BL/6J mice",
abstract = "This study was undertaken to evaluate enhancement of the chemopreventive properties of kimchi by dietary nanosized Lactobacillus (Lab.) plantarum (nLp) in an azoxymethane (AOM)/dextran sulfate sodium (DSS)– induced colitis-associated colorectal cancer C57BL/6J mouse model. nLp is a dead, shrunken, processed form of Lab. plantarum isolated from kimchi that is 0.5–1.0 μm in size. The results obtained showed that animals fed kimchi with nLp (K-nLp) had longer colons and lower colon weights/length ratios and developed fewer tumors than mice fed kimchi alone (K). In addition, K-nLp administration reduced levels of proinflammatory cytokine serum levels and mediated the mRNA and protein expressions of inflammatory, apoptotic, and cell-cycle markers to suppress inflammation and induce tumor-cell apoptosis and cell-cycle arrest. Moreover, it elevated natural killer-cell cytotoxicity. The study suggests adding nLp to kimchi could improve the suppressive effect of kimchi on AOM/DSS-induced colorectal cancer. These findings indicate nLp has potential use as a functional chemopreventive ingredient in the food industry.",
keywords = "C57BL/6J mouse, Colitis-associated colorectal cancer, Dietary nanosized lactobacillus plantarum, Kimchi",
author = "Lee, {Hyun Ah} and Hyunung Kim and Lee, {Kwang Won} and Park, {Kun Young}",
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AU - Kim, Hyunung

AU - Lee, Kwang Won

AU - Park, Kun Young

PY - 2016

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