Abstract
Objective: To examine the effects of dietary supplements on high-risk human papillomavirus (HPV) infection and cervical carcinogenesis. Methods: A multi-institutional cross-sectional study was carried out to examine whether dietary supplements were associated with the risk of cervical intraepithelial neoplasia (CIN). We enrolled 1096 women aged 18 to 65 years to participate in an HPV cohort study from March 2006 up to present. For this analysis, we included 328 HPV-positive women (166 controls; 90 CIN I and 72 CIN II/III). The details of each participant's routine dietary intake during the prior year were collected. Specific dietary supplements were classified into 5 categories, namely, multivitamins, multinutrients, vitamin C, calcium, and miscellaneous. Results: A higher HPV viral load was associated with an increased risk of CIN II/III (odds ratio [OR], 3.32; 95% confidence interval [CI], 1.54-7.16; P for trend 0.002). Dietary supplement use including multivitamins (OR, 0.21; 95% CI, 0.09-0.48), vitamins A (OR, 0.19; 95% CI, 0.07-0.53), C (OR, 0.24; 95% CI, 0.10-0.56), E (OR, 0.20; 95% CI, 0.07-0.53), and calcium (OR, 0.21; 95% CI, 0.08-0.50) was significantly associated with a lower risk of CIN II/III. The patients who took multivitamins and had a lower HPV viral load (<15.5 relative light units/positive control) had a significantly decreased frequency of CIN I (OR, 0.35; 95% CI, 0.14-0.87; interaction P = 0.925) and CIN II/III (OR, 0.11; 95% CI, 0.04-0.37; interaction P = 0.304). Conclusions: The findings of this study suggest that dietary supplements may reduce the risk of CINs in women with high-risk HPV infection.
| Original language | English |
|---|---|
| Pages (from-to) | 398-403 |
| Number of pages | 6 |
| Journal | International Journal of Gynecological Cancer |
| Volume | 20 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2010 Apr 1 |
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Keywords
- CIN
- Dietary supplements
- HPV
- Multivitamins
- Viral load
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Oncology
Cite this
Dietary supplements reduce the risk of cervical intraepithelial neoplasia. / Hwang, Jong Ha; Kim, Mi Kyung; Lee, Jae Kwan.
In: International Journal of Gynecological Cancer, Vol. 20, No. 3, 01.04.2010, p. 398-403.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dietary supplements reduce the risk of cervical intraepithelial neoplasia
AU - Hwang, Jong Ha
AU - Kim, Mi Kyung
AU - Lee, Jae Kwan
PY - 2010/4/1
Y1 - 2010/4/1
N2 - Objective: To examine the effects of dietary supplements on high-risk human papillomavirus (HPV) infection and cervical carcinogenesis. Methods: A multi-institutional cross-sectional study was carried out to examine whether dietary supplements were associated with the risk of cervical intraepithelial neoplasia (CIN). We enrolled 1096 women aged 18 to 65 years to participate in an HPV cohort study from March 2006 up to present. For this analysis, we included 328 HPV-positive women (166 controls; 90 CIN I and 72 CIN II/III). The details of each participant's routine dietary intake during the prior year were collected. Specific dietary supplements were classified into 5 categories, namely, multivitamins, multinutrients, vitamin C, calcium, and miscellaneous. Results: A higher HPV viral load was associated with an increased risk of CIN II/III (odds ratio [OR], 3.32; 95% confidence interval [CI], 1.54-7.16; P for trend 0.002). Dietary supplement use including multivitamins (OR, 0.21; 95% CI, 0.09-0.48), vitamins A (OR, 0.19; 95% CI, 0.07-0.53), C (OR, 0.24; 95% CI, 0.10-0.56), E (OR, 0.20; 95% CI, 0.07-0.53), and calcium (OR, 0.21; 95% CI, 0.08-0.50) was significantly associated with a lower risk of CIN II/III. The patients who took multivitamins and had a lower HPV viral load (<15.5 relative light units/positive control) had a significantly decreased frequency of CIN I (OR, 0.35; 95% CI, 0.14-0.87; interaction P = 0.925) and CIN II/III (OR, 0.11; 95% CI, 0.04-0.37; interaction P = 0.304). Conclusions: The findings of this study suggest that dietary supplements may reduce the risk of CINs in women with high-risk HPV infection.
AB - Objective: To examine the effects of dietary supplements on high-risk human papillomavirus (HPV) infection and cervical carcinogenesis. Methods: A multi-institutional cross-sectional study was carried out to examine whether dietary supplements were associated with the risk of cervical intraepithelial neoplasia (CIN). We enrolled 1096 women aged 18 to 65 years to participate in an HPV cohort study from March 2006 up to present. For this analysis, we included 328 HPV-positive women (166 controls; 90 CIN I and 72 CIN II/III). The details of each participant's routine dietary intake during the prior year were collected. Specific dietary supplements were classified into 5 categories, namely, multivitamins, multinutrients, vitamin C, calcium, and miscellaneous. Results: A higher HPV viral load was associated with an increased risk of CIN II/III (odds ratio [OR], 3.32; 95% confidence interval [CI], 1.54-7.16; P for trend 0.002). Dietary supplement use including multivitamins (OR, 0.21; 95% CI, 0.09-0.48), vitamins A (OR, 0.19; 95% CI, 0.07-0.53), C (OR, 0.24; 95% CI, 0.10-0.56), E (OR, 0.20; 95% CI, 0.07-0.53), and calcium (OR, 0.21; 95% CI, 0.08-0.50) was significantly associated with a lower risk of CIN II/III. The patients who took multivitamins and had a lower HPV viral load (<15.5 relative light units/positive control) had a significantly decreased frequency of CIN I (OR, 0.35; 95% CI, 0.14-0.87; interaction P = 0.925) and CIN II/III (OR, 0.11; 95% CI, 0.04-0.37; interaction P = 0.304). Conclusions: The findings of this study suggest that dietary supplements may reduce the risk of CINs in women with high-risk HPV infection.
KW - CIN
KW - Dietary supplements
KW - HPV
KW - Multivitamins
KW - Viral load
UR - http://www.scopus.com/inward/record.url?scp=77952202310&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952202310&partnerID=8YFLogxK
U2 - 10.1111/IGC.0b013e3181d02ff2
DO - 10.1111/IGC.0b013e3181d02ff2
M3 - Article
C2 - 20375804
AN - SCOPUS:77952202310
VL - 20
SP - 398
EP - 403
JO - International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
JF - International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
SN - 1048-891X
IS - 3
ER -