Differences in characteristics and comorbidity of cluster headache according to the presence of migraine

Tae Jin Song, Mi Ji Lee, Yun Ju Choi, Byung Kun Kim, Pil Wook Chung, Jung Wook Park, Min Kyung Chu, Byung Su Kim, Jong Hee Sohn, Kyungmi Oh, Daeyoung Kim, Jae Moon Kim, Soo Kyoung Kim, Kwang Yeol Park, Jae Myun Chung, Heui Soo Moon, Chin Sang Chung, Jin Young Ahn, Soo Jin Cho

Research output: Contribution to journalArticle

Abstract

Background and Purpose Cluster headache (CH) can present with migrainous symptoms such as nausea, photophobia, and phonophobia. In addition, an overlap between CH and migraine has been reported. This study aimed to determine the differences in the characteristics of CH according to the presence of comorbid migraine. Methods This study was performed using data from a prospective multicenter registry study of CH involving 16 headache clinics. CH and migraine were diagnosed by headache specialists at each hospital based on third edition of the International Classification of Headache Disorders (ICHD-3). We interviewed patients with comorbid migraine to obtain detailed information about migraine. The characteristics and psychological comorbidities of CH were compared between patients with and without comorbid migraine. Results Thirty (15.6%) of 192 patients with CH had comorbid migraine, comprising 18 with migraine without aura, 1 with migraine with aura, 3 with chronic migraine, and 8 with probable migraine. Compared to patients with CH without migraine, patients with CH with comorbid migraine had a shorter duration of CH after the first episode [5.4±7.4 vs. 9.0±8.2 years (mean±standard deviation), p=0.008], a lower frequency of episodic CH (50.0% vs. 73.5%, p= 0.010), and a higher frequency of chronic CH (13.3% vs. 3.7%, p=0.033). Psychiatric comorbidities did not differ between patients with and without comorbid migraine. The headaches experienced by patients could be distinguished based on their trigeminal autonomic symptoms, pulsating character, severity, and pain location. Conclusions Distinct characteristics of CH remained unchanged in patients with comorbid migraine with the exception of an increased frequency of chronic CH. The most appropriate management of CH requires clinicians to check the history of preceding migraine, particularly in cases of chronic CH.

Original languageEnglish
Pages (from-to)334-338
Number of pages5
JournalJournal of Clinical Neurology (Korea)
Volume15
Issue number3
DOIs
Publication statusPublished - 2019 Jul 1

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Cluster Headache
Migraine Disorders
Comorbidity
Headache
Hyperacusis
Migraine without Aura
Migraine with Aura
Photophobia
Headache Disorders

Keywords

  • Chronic cluster headache
  • Cluster headache
  • Comorbidity
  • Migraine
  • Treatment

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Differences in characteristics and comorbidity of cluster headache according to the presence of migraine. / Song, Tae Jin; Lee, Mi Ji; Choi, Yun Ju; Kim, Byung Kun; Chung, Pil Wook; Park, Jung Wook; Chu, Min Kyung; Kim, Byung Su; Sohn, Jong Hee; Oh, Kyungmi; Kim, Daeyoung; Kim, Jae Moon; Kim, Soo Kyoung; Park, Kwang Yeol; Chung, Jae Myun; Moon, Heui Soo; Chung, Chin Sang; Ahn, Jin Young; Cho, Soo Jin.

In: Journal of Clinical Neurology (Korea), Vol. 15, No. 3, 01.07.2019, p. 334-338.

Research output: Contribution to journalArticle

Song, TJ, Lee, MJ, Choi, YJ, Kim, BK, Chung, PW, Park, JW, Chu, MK, Kim, BS, Sohn, JH, Oh, K, Kim, D, Kim, JM, Kim, SK, Park, KY, Chung, JM, Moon, HS, Chung, CS, Ahn, JY & Cho, SJ 2019, 'Differences in characteristics and comorbidity of cluster headache according to the presence of migraine', Journal of Clinical Neurology (Korea), vol. 15, no. 3, pp. 334-338. https://doi.org/10.3988/jcn.2019.15.3.334
Song, Tae Jin ; Lee, Mi Ji ; Choi, Yun Ju ; Kim, Byung Kun ; Chung, Pil Wook ; Park, Jung Wook ; Chu, Min Kyung ; Kim, Byung Su ; Sohn, Jong Hee ; Oh, Kyungmi ; Kim, Daeyoung ; Kim, Jae Moon ; Kim, Soo Kyoung ; Park, Kwang Yeol ; Chung, Jae Myun ; Moon, Heui Soo ; Chung, Chin Sang ; Ahn, Jin Young ; Cho, Soo Jin. / Differences in characteristics and comorbidity of cluster headache according to the presence of migraine. In: Journal of Clinical Neurology (Korea). 2019 ; Vol. 15, No. 3. pp. 334-338.
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abstract = "Background and Purpose Cluster headache (CH) can present with migrainous symptoms such as nausea, photophobia, and phonophobia. In addition, an overlap between CH and migraine has been reported. This study aimed to determine the differences in the characteristics of CH according to the presence of comorbid migraine. Methods This study was performed using data from a prospective multicenter registry study of CH involving 16 headache clinics. CH and migraine were diagnosed by headache specialists at each hospital based on third edition of the International Classification of Headache Disorders (ICHD-3). We interviewed patients with comorbid migraine to obtain detailed information about migraine. The characteristics and psychological comorbidities of CH were compared between patients with and without comorbid migraine. Results Thirty (15.6{\%}) of 192 patients with CH had comorbid migraine, comprising 18 with migraine without aura, 1 with migraine with aura, 3 with chronic migraine, and 8 with probable migraine. Compared to patients with CH without migraine, patients with CH with comorbid migraine had a shorter duration of CH after the first episode [5.4±7.4 vs. 9.0±8.2 years (mean±standard deviation), p=0.008], a lower frequency of episodic CH (50.0{\%} vs. 73.5{\%}, p= 0.010), and a higher frequency of chronic CH (13.3{\%} vs. 3.7{\%}, p=0.033). Psychiatric comorbidities did not differ between patients with and without comorbid migraine. The headaches experienced by patients could be distinguished based on their trigeminal autonomic symptoms, pulsating character, severity, and pain location. Conclusions Distinct characteristics of CH remained unchanged in patients with comorbid migraine with the exception of an increased frequency of chronic CH. The most appropriate management of CH requires clinicians to check the history of preceding migraine, particularly in cases of chronic CH.",
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T1 - Differences in characteristics and comorbidity of cluster headache according to the presence of migraine

AU - Song, Tae Jin

AU - Lee, Mi Ji

AU - Choi, Yun Ju

AU - Kim, Byung Kun

AU - Chung, Pil Wook

AU - Park, Jung Wook

AU - Chu, Min Kyung

AU - Kim, Byung Su

AU - Sohn, Jong Hee

AU - Oh, Kyungmi

AU - Kim, Daeyoung

AU - Kim, Jae Moon

AU - Kim, Soo Kyoung

AU - Park, Kwang Yeol

AU - Chung, Jae Myun

AU - Moon, Heui Soo

AU - Chung, Chin Sang

AU - Ahn, Jin Young

AU - Cho, Soo Jin

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Background and Purpose Cluster headache (CH) can present with migrainous symptoms such as nausea, photophobia, and phonophobia. In addition, an overlap between CH and migraine has been reported. This study aimed to determine the differences in the characteristics of CH according to the presence of comorbid migraine. Methods This study was performed using data from a prospective multicenter registry study of CH involving 16 headache clinics. CH and migraine were diagnosed by headache specialists at each hospital based on third edition of the International Classification of Headache Disorders (ICHD-3). We interviewed patients with comorbid migraine to obtain detailed information about migraine. The characteristics and psychological comorbidities of CH were compared between patients with and without comorbid migraine. Results Thirty (15.6%) of 192 patients with CH had comorbid migraine, comprising 18 with migraine without aura, 1 with migraine with aura, 3 with chronic migraine, and 8 with probable migraine. Compared to patients with CH without migraine, patients with CH with comorbid migraine had a shorter duration of CH after the first episode [5.4±7.4 vs. 9.0±8.2 years (mean±standard deviation), p=0.008], a lower frequency of episodic CH (50.0% vs. 73.5%, p= 0.010), and a higher frequency of chronic CH (13.3% vs. 3.7%, p=0.033). Psychiatric comorbidities did not differ between patients with and without comorbid migraine. The headaches experienced by patients could be distinguished based on their trigeminal autonomic symptoms, pulsating character, severity, and pain location. Conclusions Distinct characteristics of CH remained unchanged in patients with comorbid migraine with the exception of an increased frequency of chronic CH. The most appropriate management of CH requires clinicians to check the history of preceding migraine, particularly in cases of chronic CH.

AB - Background and Purpose Cluster headache (CH) can present with migrainous symptoms such as nausea, photophobia, and phonophobia. In addition, an overlap between CH and migraine has been reported. This study aimed to determine the differences in the characteristics of CH according to the presence of comorbid migraine. Methods This study was performed using data from a prospective multicenter registry study of CH involving 16 headache clinics. CH and migraine were diagnosed by headache specialists at each hospital based on third edition of the International Classification of Headache Disorders (ICHD-3). We interviewed patients with comorbid migraine to obtain detailed information about migraine. The characteristics and psychological comorbidities of CH were compared between patients with and without comorbid migraine. Results Thirty (15.6%) of 192 patients with CH had comorbid migraine, comprising 18 with migraine without aura, 1 with migraine with aura, 3 with chronic migraine, and 8 with probable migraine. Compared to patients with CH without migraine, patients with CH with comorbid migraine had a shorter duration of CH after the first episode [5.4±7.4 vs. 9.0±8.2 years (mean±standard deviation), p=0.008], a lower frequency of episodic CH (50.0% vs. 73.5%, p= 0.010), and a higher frequency of chronic CH (13.3% vs. 3.7%, p=0.033). Psychiatric comorbidities did not differ between patients with and without comorbid migraine. The headaches experienced by patients could be distinguished based on their trigeminal autonomic symptoms, pulsating character, severity, and pain location. Conclusions Distinct characteristics of CH remained unchanged in patients with comorbid migraine with the exception of an increased frequency of chronic CH. The most appropriate management of CH requires clinicians to check the history of preceding migraine, particularly in cases of chronic CH.

KW - Chronic cluster headache

KW - Cluster headache

KW - Comorbidity

KW - Migraine

KW - Treatment

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