Differences in hepatic gene expression as a major distinguishing factor between Korean native pig and Yorkshire

Seung Soo Kim, So Ra Kim, Jung Rok Kim, Jin Kyoo Moon, Bong Hwan Choi, Jae Won Lee, Kwan Suk Kim, Tae Hun Kim, Hyun Jung Kim, Cheol-Koo Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

There are phenotypic differences between Korean native pig (KNP) and Yorkshire (YS) breeds due to different interests in selection. YS has been selected for industrial interests such as a growth rate and lean meat production, while KNP has been maintained as a regional breed with local interests such as disease resistance and fat content in and between muscle. A comparison of gene expression profiles from liver tissue reflected overall long-term effects of artificial selection for these two pig breeds. Based on minimum positive false discovery rate (less than 10%) and fold change (|FC| > 1:5), 73 differentially expressed genes (DEGs) were identified. Functional analysis of these DEGs indicated clear distinctions in signaling capacity related to epidermal growth factor (EGF), extracellular structure, protein metabolism, and detoxification. Hepatic DEGs demonstrated the importance of hormonal and metabolic capabilities to differences between these two pig breeds.

Original languageEnglish
Pages (from-to)451-458
Number of pages8
JournalBioscience, Biotechnology and Biochemistry
Volume75
Issue number3
DOIs
Publication statusPublished - 2011 Apr 13

Fingerprint

Gene expression
Swine
Genes
Gene Expression
Liver
Detoxification
Functional analysis
Meats
Epidermal Growth Factor
Metabolism
Disease Resistance
Muscle
Fats
Transcriptome
Meat
Tissue
Muscles
Proteins
Growth

Keywords

  • Differentially expressed gene
  • Gene expression profile
  • Korean native pig
  • Liver
  • Yorkshire

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry

Cite this

Differences in hepatic gene expression as a major distinguishing factor between Korean native pig and Yorkshire. / Kim, Seung Soo; Kim, So Ra; Kim, Jung Rok; Moon, Jin Kyoo; Choi, Bong Hwan; Lee, Jae Won; Kim, Kwan Suk; Kim, Tae Hun; Kim, Hyun Jung; Lee, Cheol-Koo.

In: Bioscience, Biotechnology and Biochemistry, Vol. 75, No. 3, 13.04.2011, p. 451-458.

Research output: Contribution to journalArticle

Kim, Seung Soo ; Kim, So Ra ; Kim, Jung Rok ; Moon, Jin Kyoo ; Choi, Bong Hwan ; Lee, Jae Won ; Kim, Kwan Suk ; Kim, Tae Hun ; Kim, Hyun Jung ; Lee, Cheol-Koo. / Differences in hepatic gene expression as a major distinguishing factor between Korean native pig and Yorkshire. In: Bioscience, Biotechnology and Biochemistry. 2011 ; Vol. 75, No. 3. pp. 451-458.
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