Differences in prognosis and efficacy of chemotherapy by p53 expression in triple-negative breast cancer

Soo Youn Bae, Seok Jin Nam, Yongsik Jung, Sae Byul Lee, Byung Woo Park, Woosung Lim, Sung Hoo Jung, Hsien Wen Yang, Seung Pil Jung

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7 Citations (Scopus)

Abstract

Purpose: TP53 mutation is the most common mutation in breast cancer, and it is considered a target marker of triple-negative breast cancer (TNBC). We investigated whether expression of p53 detected by immunochemical staining predicts the chemotherapy response of TNBC. Methods: A total of 11,393 TNBC patients who had between stage I and stage III enrolled in the Korean Breast Cancer Society Registry database from January 1, 2000 to December 31, 2015. There were 6,331 ‘p53-positive (+) TNBC’ patients and 5062 ‘p53-negative (−) TNBC’ patients. Results: In univariate analysis, p53(+) TNBC had a worse prognosis than p53(−) TNBC in patients not receiving chemotherapy (P = 0.003). However, there was no difference in prognosis between p53(+) TNBC and p53(−) TNBC for patients receiving chemotherapy. In multivariate analysis adjusted for age and stage, the risk of p53(+) TNBC was 1.84 times higher than that of p53(−) TNBC in the non-chemotherapy group. However, there was no difference between p53(+) TNBC and p53(−) TNBC in patients receiving chemotherapy. In p53(+) TNBC, the risk was 0.6-fold lower when chemotherapy was administered than when chemotherapy was not administered. However, in p53(−) TNBC, there was no risk reduction effect by chemotherapy. Conclusion: The prognosis of p53(+) TNBC has worse than p53(−) TNBC, but the risk for survival was significantly reduced with chemotherapy. It suggests that p53(+) TNBC would be more sensitive to chemotherapy than p53(−) TNBC.

Original languageEnglish
JournalBreast Cancer Research and Treatment
DOIs
Publication statusAccepted/In press - 2018 Jan 1

Keywords

  • Chemotherapy
  • Immunohistochemistry
  • P53
  • Prognosis
  • Triple-negative breast cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Bae, S. Y., Nam, S. J., Jung, Y., Lee, S. B., Park, B. W., Lim, W., Jung, S. H., Yang, H. W., & Jung, S. P. (Accepted/In press). Differences in prognosis and efficacy of chemotherapy by p53 expression in triple-negative breast cancer. Breast Cancer Research and Treatment. https://doi.org/10.1007/s10549-018-4928-2