Differences in prognosis by p53 expression after neoadjuvant chemotherapy in triple-negative breast cancer

Soo Youn Bae, Jeong Hyeon Lee, Jeoung Won Bae, Seung Pil Jung

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Purpose: Our previous studies suggested that p53-positive triple-negative breast cancer (TNBC) should be more sensitive to chemotherapy than p53-negative TNBC. The aim of this study was to determine whether p53 expression in TNBC could predict response to neoadjuvant chemotherapy and the resulting prognosis. Methods: From January 2009 to December 2017, TNBC patients who underwent neoadjuvant chemotherapy were reviewed, including a total of 31 TNBC patients who had clinical lymph node metastasis. The status of p53 expression in patients before and after chemotherapy was evaluated. Results: Two patients (22.2%, 2 of 9) achieved pCR in p53(+) TNBC and 4 patients (50%, 5 of 10) achieved pCR in p53(-) TNBC. There was no correlation between pCR rate and p53 expression (P = 0.350). Based on prechemotherapy p53 expression, there was no significant difference in disease-free survival (DFS) between p53(+) TNBC and p53(-) TNBC (P = 0.335). However, after chemotherapy, p53(+) TNBC had shown higher DFS than p53(-) TBNC (P = 0.099). Based on prechemotherapy p53 expression, p53(+) TNBC had better overall survival (OS) than p53(-) TNBC, but the difference was not statistically significant (P = 0.082). After chemotherapy, p53(+) TNBC showed significantly better OS than p53(-) TNBC (P = 0.018). Conclusion: Immunohistochemically detected p53 expression in TNBC could not predict the response to neoadjuvant chemotherapy. However, p53(+) TNBC had a better OS than p53(-) TNBC in patients who underwent neoadjuvant chemotherapy.

Original languageEnglish
Pages (from-to)291-298
Number of pages8
JournalAnnals of Surgical Treatment and Research
Volume98
Issue number6
DOIs
Publication statusPublished - 2020 Jun

Keywords

  • Immunohistochemistry
  • Neoadjuvant therapy
  • Prognosis
  • Triple negative breast neoplasms
  • Tumor suppressor potein p53

ASJC Scopus subject areas

  • Surgery

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