Differences in Tumor Characteristics and Prognosis in Newly Diagnosed Ta, T1 Urothelial Carcinoma of Bladder According to Patient Age

Kang Su Cho, Tae Kon Hwang, Bup Wan Kim, Duck Ki Yoon, Sung Goo Chang, Se Joong Kim, Jong Yeon Park, Jun Cheon, Gyung Tak Sung, Sung Joon Hong

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Abstract

Objectives: To evaluate the differences in tumor characteristics and prognosis according to age at presentation in patients with newly diagnosed Stage Ta, T1 urothelial carcinoma of the bladder. Methods: From 1998 to 2002, 1587 patients with newly diagnosed nonmuscle-invasive bladder cancer treated with transurethral resection were enrolled in this study. The median age was 63 years (range 21-98), and the median follow-up duration was 44 months (range 12-97). The study cohort was subdivided into 3 age groups: age <60 years (group 1, n = 614), age ≥60 but <70 years (group 2, n = 566), and age ≥70 years (group 3, n = 398). Results: Comparing the clinical and pathologic characteristics, the tumor size (χ2 trend = 4.01, P = .045), multiplicity (χ2 trend = 14.50, P < .001), T category (χ2 trend = 17.11, P < .001), and tumor grade (χ2 trend = 31.36, P < .001) tended to increase in the older age groups. The presence of carcinoma in situ and squamous differentiation, however, did not differ among the age groups (P > .05). The 5-year recurrence-free probability was 63.6%, 52.1%, and 43.9% for groups 1, 2, and 3, respectively (P < .001). The 5-year progression-free probability was 95.7%, 91.1%, and 84.2% for groups 1, 2, and 3, respectively (P < .001). Conclusions: Stage Ta, T1 bladder urothelial carcinoma in the younger patients tended to be smaller, have fewer lesions, be less invasive, and have a more favorable tumor grade at the initial presentation. Furthermore, younger patients appeared to have a more favorable prognosis than older patients.

Original languageEnglish
JournalUrology
Volume73
Issue number4
DOIs
Publication statusPublished - 2009 Apr 1

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Urinary Bladder
Carcinoma
Neoplasms
Urinary Bladder Neoplasms
Cohort Studies
Age Groups
Recurrence

ASJC Scopus subject areas

  • Urology

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Differences in Tumor Characteristics and Prognosis in Newly Diagnosed Ta, T1 Urothelial Carcinoma of Bladder According to Patient Age. / Cho, Kang Su; Hwang, Tae Kon; Kim, Bup Wan; Yoon, Duck Ki; Chang, Sung Goo; Kim, Se Joong; Park, Jong Yeon; Cheon, Jun; Sung, Gyung Tak; Hong, Sung Joon.

In: Urology, Vol. 73, No. 4, 01.04.2009.

Research output: Contribution to journalArticle

Cho, Kang Su ; Hwang, Tae Kon ; Kim, Bup Wan ; Yoon, Duck Ki ; Chang, Sung Goo ; Kim, Se Joong ; Park, Jong Yeon ; Cheon, Jun ; Sung, Gyung Tak ; Hong, Sung Joon. / Differences in Tumor Characteristics and Prognosis in Newly Diagnosed Ta, T1 Urothelial Carcinoma of Bladder According to Patient Age. In: Urology. 2009 ; Vol. 73, No. 4.
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title = "Differences in Tumor Characteristics and Prognosis in Newly Diagnosed Ta, T1 Urothelial Carcinoma of Bladder According to Patient Age",
abstract = "Objectives: To evaluate the differences in tumor characteristics and prognosis according to age at presentation in patients with newly diagnosed Stage Ta, T1 urothelial carcinoma of the bladder. Methods: From 1998 to 2002, 1587 patients with newly diagnosed nonmuscle-invasive bladder cancer treated with transurethral resection were enrolled in this study. The median age was 63 years (range 21-98), and the median follow-up duration was 44 months (range 12-97). The study cohort was subdivided into 3 age groups: age <60 years (group 1, n = 614), age ≥60 but <70 years (group 2, n = 566), and age ≥70 years (group 3, n = 398). Results: Comparing the clinical and pathologic characteristics, the tumor size (χ2 trend = 4.01, P = .045), multiplicity (χ2 trend = 14.50, P < .001), T category (χ2 trend = 17.11, P < .001), and tumor grade (χ2 trend = 31.36, P < .001) tended to increase in the older age groups. The presence of carcinoma in situ and squamous differentiation, however, did not differ among the age groups (P > .05). The 5-year recurrence-free probability was 63.6{\%}, 52.1{\%}, and 43.9{\%} for groups 1, 2, and 3, respectively (P < .001). The 5-year progression-free probability was 95.7{\%}, 91.1{\%}, and 84.2{\%} for groups 1, 2, and 3, respectively (P < .001). Conclusions: Stage Ta, T1 bladder urothelial carcinoma in the younger patients tended to be smaller, have fewer lesions, be less invasive, and have a more favorable tumor grade at the initial presentation. Furthermore, younger patients appeared to have a more favorable prognosis than older patients.",
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T1 - Differences in Tumor Characteristics and Prognosis in Newly Diagnosed Ta, T1 Urothelial Carcinoma of Bladder According to Patient Age

AU - Cho, Kang Su

AU - Hwang, Tae Kon

AU - Kim, Bup Wan

AU - Yoon, Duck Ki

AU - Chang, Sung Goo

AU - Kim, Se Joong

AU - Park, Jong Yeon

AU - Cheon, Jun

AU - Sung, Gyung Tak

AU - Hong, Sung Joon

PY - 2009/4/1

Y1 - 2009/4/1

N2 - Objectives: To evaluate the differences in tumor characteristics and prognosis according to age at presentation in patients with newly diagnosed Stage Ta, T1 urothelial carcinoma of the bladder. Methods: From 1998 to 2002, 1587 patients with newly diagnosed nonmuscle-invasive bladder cancer treated with transurethral resection were enrolled in this study. The median age was 63 years (range 21-98), and the median follow-up duration was 44 months (range 12-97). The study cohort was subdivided into 3 age groups: age <60 years (group 1, n = 614), age ≥60 but <70 years (group 2, n = 566), and age ≥70 years (group 3, n = 398). Results: Comparing the clinical and pathologic characteristics, the tumor size (χ2 trend = 4.01, P = .045), multiplicity (χ2 trend = 14.50, P < .001), T category (χ2 trend = 17.11, P < .001), and tumor grade (χ2 trend = 31.36, P < .001) tended to increase in the older age groups. The presence of carcinoma in situ and squamous differentiation, however, did not differ among the age groups (P > .05). The 5-year recurrence-free probability was 63.6%, 52.1%, and 43.9% for groups 1, 2, and 3, respectively (P < .001). The 5-year progression-free probability was 95.7%, 91.1%, and 84.2% for groups 1, 2, and 3, respectively (P < .001). Conclusions: Stage Ta, T1 bladder urothelial carcinoma in the younger patients tended to be smaller, have fewer lesions, be less invasive, and have a more favorable tumor grade at the initial presentation. Furthermore, younger patients appeared to have a more favorable prognosis than older patients.

AB - Objectives: To evaluate the differences in tumor characteristics and prognosis according to age at presentation in patients with newly diagnosed Stage Ta, T1 urothelial carcinoma of the bladder. Methods: From 1998 to 2002, 1587 patients with newly diagnosed nonmuscle-invasive bladder cancer treated with transurethral resection were enrolled in this study. The median age was 63 years (range 21-98), and the median follow-up duration was 44 months (range 12-97). The study cohort was subdivided into 3 age groups: age <60 years (group 1, n = 614), age ≥60 but <70 years (group 2, n = 566), and age ≥70 years (group 3, n = 398). Results: Comparing the clinical and pathologic characteristics, the tumor size (χ2 trend = 4.01, P = .045), multiplicity (χ2 trend = 14.50, P < .001), T category (χ2 trend = 17.11, P < .001), and tumor grade (χ2 trend = 31.36, P < .001) tended to increase in the older age groups. The presence of carcinoma in situ and squamous differentiation, however, did not differ among the age groups (P > .05). The 5-year recurrence-free probability was 63.6%, 52.1%, and 43.9% for groups 1, 2, and 3, respectively (P < .001). The 5-year progression-free probability was 95.7%, 91.1%, and 84.2% for groups 1, 2, and 3, respectively (P < .001). Conclusions: Stage Ta, T1 bladder urothelial carcinoma in the younger patients tended to be smaller, have fewer lesions, be less invasive, and have a more favorable tumor grade at the initial presentation. Furthermore, younger patients appeared to have a more favorable prognosis than older patients.

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