Different expression patterns of Phactr family members in normal and injured mouse brain

J. Y. Kim, S. Y. Choi, Y. Moon, H. J. Kim, J. H. Chin, Hyun Kim, Woong Sun

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Phosphatase and actin regulators (Phactrs) are a novel family of proteins expressed in the brain, and they exhibit both strong modulatory activity of protein phosphatase 1 and actin-binding activity. Phactrs are comprised of four family members (Phactr1-4), but their detailed expression patterns during embryonic and postnatal development are not well understood. We found that these family members exhibit different spatiotemporal mRNA expression patterns. Phactr4 mRNA was found in neural stem cells in the developing and adult brains, whereas Phactr1 and 3 appeared to be expressed in post-mitotic neurons. Following traumatic brain injury which promotes neurogenesis in the neurogenic region and gliogenesis in the injury penumbra, the mRNA expression of phactr2 and 4 was progressively increased in the injury penumbra, and phactr4 mRNA and protein induction was observed in reactive astrocytes. These differential expression patterns of phactrs imply specific functions for each protein during development, and the importance of Phactr4 in the reactive gliosis following brain injury.

Original languageEnglish
Pages (from-to)37-46
Number of pages10
JournalNeuroscience
Volume221
DOIs
Publication statusPublished - 2012 Sep 27

Fingerprint

Actins
Messenger RNA
Brain
Phosphoric Monoester Hydrolases
Protein Phosphatase 1
Proteins
Gliosis
Neural Stem Cells
Neurogenesis
Wounds and Injuries
Astrocytes
Brain Injuries
Embryonic Development
Neurons
Traumatic Brain Injury

Keywords

  • In situ hybridization
  • Neural stem/progenitor cell
  • Phactrs
  • Traumatic brain injury

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Different expression patterns of Phactr family members in normal and injured mouse brain. / Kim, J. Y.; Choi, S. Y.; Moon, Y.; Kim, H. J.; Chin, J. H.; Kim, Hyun; Sun, Woong.

In: Neuroscience, Vol. 221, 27.09.2012, p. 37-46.

Research output: Contribution to journalArticle

Kim, J. Y. ; Choi, S. Y. ; Moon, Y. ; Kim, H. J. ; Chin, J. H. ; Kim, Hyun ; Sun, Woong. / Different expression patterns of Phactr family members in normal and injured mouse brain. In: Neuroscience. 2012 ; Vol. 221. pp. 37-46.
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