Different gamma-glutamyl transpeptidase mRNAs are expressed in human liver and kidney

André Pawlak, Shi Jun Wu, Frédérique Bulle, Atsuo Suzuki, Naima Chikhi, Nicolas Ferry, Ja Hyun Baik, Sylvie Siegrist, Georges Guellaën

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

In human, the two subunits of gamma-glutamyl transpeptidase (GGT) arise from a common precursor encoded by a multigene family. Until now, a single specific coding sequence for this precursor (type I) has been identified in human placenta and liver. In the present study, we have isolated from a human kidney cDNA library, a GGT specific clone (0.8 Kb). The sequence of which (type II) i) covers the carboxy terminal part of the GGT precursor, ii) exhibits 22 point mutations and a 30 bp deletion as compared to the type I GGT sequence. The sequencing of a human genomic clone reveals that this type II GGT mRNA is encoded by a different gene than the type I GGT mRNA. Both type I and type II GGT mRNAs are expressed in human liver, while almost exclusively type II GGT mRNA is detected in human kidney.

Original languageEnglish
Pages (from-to)912-918
Number of pages7
JournalBiochemical and biophysical research communications
Volume164
Issue number2
DOIs
Publication statusPublished - 1989 Oct 31

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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