Different Roles of Dendritic Cells for Chronic Rhinosinusitis Treatment According to Phenotype

Junhu Tai; Jiwon Kwak; Munsoo Han; Tae Hoon Kim

doi:10.3390/ijms23148032

Different Roles of Dendritic Cells for Chronic Rhinosinusitis Treatment According to Phenotype

Junhu Tai, Jiwon Kwak, Munsoo Han, Tae Hoon Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

Dendritic cells (DCs) are antigen-presenting cells derived from the bone marrow that play an important role in the association between the innate and adaptive immune responses. The onset and development of chronic rhinosinusitis (CRS) involve a serious imbalance in immune regulation and mechanical dysfunction caused by an abnormal remodeling process. Recent studies have shown that an increase in DCs in CRS and their function of shaping the nasal mucosal immune response may play an important role in the pathogenesis of CRS. In this review, we discuss DC subsets in mice and humans, as well as the function of DCs in the nasal sinus mucosa. In addition, the mechanism by which DCs can be used as targets for therapeutic intervention for CRS and potential future research directions are also discussed.

Original language	English
Article number	8032
Journal	International journal of molecular sciences
Volume	23
Issue number	14
DOIs	https://doi.org/10.3390/ijms23148032
Publication status	Published - 2022 Jul

Keywords

chronic rhinosinusitis
dendritic cells
immunity
phenotype

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.3390/ijms23148032

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title = "Different Roles of Dendritic Cells for Chronic Rhinosinusitis Treatment According to Phenotype",

abstract = "Dendritic cells (DCs) are antigen-presenting cells derived from the bone marrow that play an important role in the association between the innate and adaptive immune responses. The onset and development of chronic rhinosinusitis (CRS) involve a serious imbalance in immune regulation and mechanical dysfunction caused by an abnormal remodeling process. Recent studies have shown that an increase in DCs in CRS and their function of shaping the nasal mucosal immune response may play an important role in the pathogenesis of CRS. In this review, we discuss DC subsets in mice and humans, as well as the function of DCs in the nasal sinus mucosa. In addition, the mechanism by which DCs can be used as targets for therapeutic intervention for CRS and potential future research directions are also discussed.",

keywords = "chronic rhinosinusitis, dendritic cells, immunity, phenotype",

author = "Junhu Tai and Jiwon Kwak and Munsoo Han and Kim, {Tae Hoon}",

note = "Funding Information: This research was supported by the Basic Science Research Program, National Research Foundation of Korea, funded by the Ministry of Science and Technology and the Ministry of Science, ICT and Future Planning (2017R1A2B2003575 and NRF-2020R1A2C1006398); the Ministry of Science and ICT, Korea, under the ICT Creative Consilience program (IITP-2022-2020-0-01819), supervised by the Institute for Information and Communications Technology Planning and Evaluation (IITP); and the Korea Health Technology R&D Project (HI17C0387, HI22C1302) through Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare. This research was also supported by a Korea University grant and a grant from the Korea University Medical Center and Anam Hospital in Seoul, Republic of Korea. Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

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doi = "10.3390/ijms23148032",

language = "English",

volume = "23",

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AU - Tai, Junhu

AU - Kwak, Jiwon

AU - Han, Munsoo

AU - Kim, Tae Hoon

N1 - Funding Information: This research was supported by the Basic Science Research Program, National Research Foundation of Korea, funded by the Ministry of Science and Technology and the Ministry of Science, ICT and Future Planning (2017R1A2B2003575 and NRF-2020R1A2C1006398); the Ministry of Science and ICT, Korea, under the ICT Creative Consilience program (IITP-2022-2020-0-01819), supervised by the Institute for Information and Communications Technology Planning and Evaluation (IITP); and the Korea Health Technology R&D Project (HI17C0387, HI22C1302) through Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare. This research was also supported by a Korea University grant and a grant from the Korea University Medical Center and Anam Hospital in Seoul, Republic of Korea. Publisher Copyright: © 2022 by the authors.

PY - 2022/7

Y1 - 2022/7

N2 - Dendritic cells (DCs) are antigen-presenting cells derived from the bone marrow that play an important role in the association between the innate and adaptive immune responses. The onset and development of chronic rhinosinusitis (CRS) involve a serious imbalance in immune regulation and mechanical dysfunction caused by an abnormal remodeling process. Recent studies have shown that an increase in DCs in CRS and their function of shaping the nasal mucosal immune response may play an important role in the pathogenesis of CRS. In this review, we discuss DC subsets in mice and humans, as well as the function of DCs in the nasal sinus mucosa. In addition, the mechanism by which DCs can be used as targets for therapeutic intervention for CRS and potential future research directions are also discussed.

AB - Dendritic cells (DCs) are antigen-presenting cells derived from the bone marrow that play an important role in the association between the innate and adaptive immune responses. The onset and development of chronic rhinosinusitis (CRS) involve a serious imbalance in immune regulation and mechanical dysfunction caused by an abnormal remodeling process. Recent studies have shown that an increase in DCs in CRS and their function of shaping the nasal mucosal immune response may play an important role in the pathogenesis of CRS. In this review, we discuss DC subsets in mice and humans, as well as the function of DCs in the nasal sinus mucosa. In addition, the mechanism by which DCs can be used as targets for therapeutic intervention for CRS and potential future research directions are also discussed.

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M3 - Review article

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Different Roles of Dendritic Cells for Chronic Rhinosinusitis Treatment According to Phenotype

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Keywords

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