Different strains and substrains of rats show different levels of neuropathic pain behaviors

Young Wook Yoon, Doo Hyun Lee, Bae Hwan Lee, Kyungsoon Chung, Jin Mo Chung

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

This study compared and contrasted the manifestation of neuropathic pain behaviors in several strains of rats. These included ACI, Brown-Norway, Fischer 344, Lewis, Long-Evans, Sprague-Dawley, and Wistar-Furth, all obtained from Harlan Sprague-Dawley Inc. Comparison was also made between two substrains of Sprague-Dawley rats: one from Harlan and the other from Sasco. Neuropathic injury was produced by tightly ligating the left L5 and L6 spinal nerves with the animals under halothane anesthesia. Tests were conducted for 2 weeks to examine behavioral signs representing mechanical allodynia, cold allodynia, and spontaneous pain. There was no difference between strains in any of the tested behaviors before surgery. After neuropathic injury, rats in most groups developed high levels of behavioral signs of various components of neuropathic pain: however, some strains of rats showed weak behavioral signs of neuropathic pain. When a comparison was made between two substrains of Sprague-Dawley rats from two different sources, the ones from Sasco showed weaker behavioral signs than those from Harlan. When comparisons were made between different strains of rats from the same source (Harlan), Brown-Norway and Long-Evans rats showed the smallest magnitude of neuropathic pain behaviors. The data indicate that different strains and substrains of rats display different degrees of pain behaviors, suggesting that strains and substrains are important variables in the development of neuropathic pain after peripheral nerve injury.

Original languageEnglish
Pages (from-to)167-171
Number of pages5
JournalExperimental Brain Research
Volume129
Issue number2
DOIs
Publication statusPublished - 1999 Nov 19
Externally publishedYes

Fingerprint

Neuralgia
Hyperalgesia
Norway
Sprague Dawley Rats
Pain
Peripheral Nerve Injuries
Spinal Nerves
Long Evans Rats
Wounds and Injuries
Halothane
Anesthesia

Keywords

  • Causalgia
  • Hyperalgesia
  • Mechanical allodynia
  • Peripheral nerve injury
  • Sympathetically maintained pain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Different strains and substrains of rats show different levels of neuropathic pain behaviors. / Yoon, Young Wook; Lee, Doo Hyun; Lee, Bae Hwan; Chung, Kyungsoon; Chung, Jin Mo.

In: Experimental Brain Research, Vol. 129, No. 2, 19.11.1999, p. 167-171.

Research output: Contribution to journalArticle

Yoon, Young Wook ; Lee, Doo Hyun ; Lee, Bae Hwan ; Chung, Kyungsoon ; Chung, Jin Mo. / Different strains and substrains of rats show different levels of neuropathic pain behaviors. In: Experimental Brain Research. 1999 ; Vol. 129, No. 2. pp. 167-171.
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