Different therapeutic responses in chronic obstructive pulmonary disease subgroups

J. S. Lee, J. W. Huh, E. J. Chae, J. B. Seo, S. W. Ra, J. H. Lee, E. K. Kim, Y. K. Lee, T. H. Kim, W. J. Kim, J. H. Lee, S. M. Lee, S. Lee, S. Y. Lim, T. R. Shin, H. I. Yoon, S. S. Sheen, Yeon Mok Oh, Sang Do Lee

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12 Citations (Scopus)

Abstract

SETTING: Eleven referring hospitals in South Korea. OBJECTIVE: To compare therapeutic responses in chronic obstructive pulmonary disease (COPD) subgroups, classifi ed by diffusing capacity of the lung for carbon monoxide (DL CO) and lung volume. DESIGN: A total of 130 stable male COPD patients were classified into four subgroups according to baseline DLCO and residual volume/total lung capacity (RV/TLC) ratio. We compared therapeutic responses to short acting β2-agonist (SABA) and 3-month combined inhalation of long-acting β2-agonist (LABA) and corticosteroid among patients with these subgroups. RESULTS: Among the 130 COPD patients, 41 (31.5%) had normal DLCO and RV/TLC, 28 (21.5%) low DLCO and normal RV/TLC, 31 (23.8%) normal DLCO and high RV/TLC, and 30 (23.1%) low DLCO and high RV/TLC. The normal DLCO/high RV/TLC subgroup showed a signifi-cantly larger flow response (changes in forced expiratory volume in 1 s) to salbutamol than the normal DLCO/RV/TLC subgroups, and a larger volume response (changes in forced vital capacity) than the two normal RV/TLC subgroups. The normal DLCO/high RV/TLC subgroup also showed significantly larger flow and volume response to 3-month combined inhalation of LABA and corticosteroid than the two normal RV/TLC subgroups. CONCLUSION: COPD subgroups classified by DLCO and RV/TLC may have different pulmonary function responses to pharmacological treatment.

Original languageEnglish
Pages (from-to)1104-1110
Number of pages7
JournalInternational Journal of Tuberculosis and Lung Disease
Volume15
Issue number8
DOIs
Publication statusPublished - 2011 Aug

Keywords

  • COPD
  • Diffusing capacity
  • Emphysema
  • Lung volume

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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    Lee, J. S., Huh, J. W., Chae, E. J., Seo, J. B., Ra, S. W., Lee, J. H., Kim, E. K., Lee, Y. K., Kim, T. H., Kim, W. J., Lee, J. H., Lee, S. M., Lee, S., Lim, S. Y., Shin, T. R., Yoon, H. I., Sheen, S. S., Oh, Y. M., & Lee, S. D. (2011). Different therapeutic responses in chronic obstructive pulmonary disease subgroups. International Journal of Tuberculosis and Lung Disease, 15(8), 1104-1110. https://doi.org/10.5588/ijtld.10.0553