Differential effect of previous antiplatelet use on stroke severity according to stroke mechanism

Wook Joo Kim, Youngchai Ko, Mi Hwa Yang, Sun Hye Im, Jung Hyun Park, Jisung Lee, Juneyoung Lee, Moon Ku Han, Hee Joon Bae

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background and Purpose: The effect of previous antiplatelet use on stroke severity is controversial. We assume that this controversy is attributable to its difference according to the stroke mechanism. Methods: Using a prospective stroke registry, patients who were hospitalized because of ischemic stroke and had relevant lesions on MRI were selected. Patients who were using anticoagulants or whose stroke subtype was categorized as stroke of other determined etiology or undetermined etiology were excluded. Baseline stroke severity was measured using the National Institutes of Health Stroke Scale scores at presentation and was compared between no previous antiplatelet users and previous antiplatelet users with stratification by stroke subtypes. RESULTS: Among the 1622 patients, a total of 490 (30.2%) patients reported use of an antiplatelet within 1 week of stroke onset. The baseline National Institutes of Health Stroke Scale score showed no difference between the nonantiplatelet and antiplatelet groups by crude comparison. However, the interaction between previous antiplatelet use and stroke subtype was significant (P≤0.023) in a multivariable analysis; when the study subjects were stratified by stroke subtype, the difference in baseline National Institutes of Health Stroke Scale between the nonantiplatelet and platelet groups was significant in the large artery atherothrombosis group but not in those with cardioembolism and small-vessel occlusion before and after adjustments. Conclusions: Our study suggests that the reduction of initial stroke severity in the previous antiplatelet users may differ by stroke mechanism.

Original languageEnglish
Pages (from-to)1200-1204
Number of pages5
JournalStroke
Volume41
Issue number6
DOIs
Publication statusPublished - 2010 Jun 1

Fingerprint

Stroke
National Institutes of Health (U.S.)
Anticoagulants
Registries
Blood Platelets
Arteries

Keywords

  • Antiplatelet drugs
  • Cerebral infarction
  • Stroke classification

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

Cite this

Kim, W. J., Ko, Y., Yang, M. H., Im, S. H., Park, J. H., Lee, J., ... Bae, H. J. (2010). Differential effect of previous antiplatelet use on stroke severity according to stroke mechanism. Stroke, 41(6), 1200-1204. https://doi.org/10.1161/STROKEAHA.110.580225

Differential effect of previous antiplatelet use on stroke severity according to stroke mechanism. / Kim, Wook Joo; Ko, Youngchai; Yang, Mi Hwa; Im, Sun Hye; Park, Jung Hyun; Lee, Jisung; Lee, Juneyoung; Han, Moon Ku; Bae, Hee Joon.

In: Stroke, Vol. 41, No. 6, 01.06.2010, p. 1200-1204.

Research output: Contribution to journalArticle

Kim, WJ, Ko, Y, Yang, MH, Im, SH, Park, JH, Lee, J, Lee, J, Han, MK & Bae, HJ 2010, 'Differential effect of previous antiplatelet use on stroke severity according to stroke mechanism', Stroke, vol. 41, no. 6, pp. 1200-1204. https://doi.org/10.1161/STROKEAHA.110.580225
Kim, Wook Joo ; Ko, Youngchai ; Yang, Mi Hwa ; Im, Sun Hye ; Park, Jung Hyun ; Lee, Jisung ; Lee, Juneyoung ; Han, Moon Ku ; Bae, Hee Joon. / Differential effect of previous antiplatelet use on stroke severity according to stroke mechanism. In: Stroke. 2010 ; Vol. 41, No. 6. pp. 1200-1204.
@article{3e7520a5479b492aba499b301543b991,
title = "Differential effect of previous antiplatelet use on stroke severity according to stroke mechanism",
abstract = "Background and Purpose: The effect of previous antiplatelet use on stroke severity is controversial. We assume that this controversy is attributable to its difference according to the stroke mechanism. Methods: Using a prospective stroke registry, patients who were hospitalized because of ischemic stroke and had relevant lesions on MRI were selected. Patients who were using anticoagulants or whose stroke subtype was categorized as stroke of other determined etiology or undetermined etiology were excluded. Baseline stroke severity was measured using the National Institutes of Health Stroke Scale scores at presentation and was compared between no previous antiplatelet users and previous antiplatelet users with stratification by stroke subtypes. RESULTS: Among the 1622 patients, a total of 490 (30.2{\%}) patients reported use of an antiplatelet within 1 week of stroke onset. The baseline National Institutes of Health Stroke Scale score showed no difference between the nonantiplatelet and antiplatelet groups by crude comparison. However, the interaction between previous antiplatelet use and stroke subtype was significant (P≤0.023) in a multivariable analysis; when the study subjects were stratified by stroke subtype, the difference in baseline National Institutes of Health Stroke Scale between the nonantiplatelet and platelet groups was significant in the large artery atherothrombosis group but not in those with cardioembolism and small-vessel occlusion before and after adjustments. Conclusions: Our study suggests that the reduction of initial stroke severity in the previous antiplatelet users may differ by stroke mechanism.",
keywords = "Antiplatelet drugs, Cerebral infarction, Stroke classification",
author = "Kim, {Wook Joo} and Youngchai Ko and Yang, {Mi Hwa} and Im, {Sun Hye} and Park, {Jung Hyun} and Jisung Lee and Juneyoung Lee and Han, {Moon Ku} and Bae, {Hee Joon}",
year = "2010",
month = "6",
day = "1",
doi = "10.1161/STROKEAHA.110.580225",
language = "English",
volume = "41",
pages = "1200--1204",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Differential effect of previous antiplatelet use on stroke severity according to stroke mechanism

AU - Kim, Wook Joo

AU - Ko, Youngchai

AU - Yang, Mi Hwa

AU - Im, Sun Hye

AU - Park, Jung Hyun

AU - Lee, Jisung

AU - Lee, Juneyoung

AU - Han, Moon Ku

AU - Bae, Hee Joon

PY - 2010/6/1

Y1 - 2010/6/1

N2 - Background and Purpose: The effect of previous antiplatelet use on stroke severity is controversial. We assume that this controversy is attributable to its difference according to the stroke mechanism. Methods: Using a prospective stroke registry, patients who were hospitalized because of ischemic stroke and had relevant lesions on MRI were selected. Patients who were using anticoagulants or whose stroke subtype was categorized as stroke of other determined etiology or undetermined etiology were excluded. Baseline stroke severity was measured using the National Institutes of Health Stroke Scale scores at presentation and was compared between no previous antiplatelet users and previous antiplatelet users with stratification by stroke subtypes. RESULTS: Among the 1622 patients, a total of 490 (30.2%) patients reported use of an antiplatelet within 1 week of stroke onset. The baseline National Institutes of Health Stroke Scale score showed no difference between the nonantiplatelet and antiplatelet groups by crude comparison. However, the interaction between previous antiplatelet use and stroke subtype was significant (P≤0.023) in a multivariable analysis; when the study subjects were stratified by stroke subtype, the difference in baseline National Institutes of Health Stroke Scale between the nonantiplatelet and platelet groups was significant in the large artery atherothrombosis group but not in those with cardioembolism and small-vessel occlusion before and after adjustments. Conclusions: Our study suggests that the reduction of initial stroke severity in the previous antiplatelet users may differ by stroke mechanism.

AB - Background and Purpose: The effect of previous antiplatelet use on stroke severity is controversial. We assume that this controversy is attributable to its difference according to the stroke mechanism. Methods: Using a prospective stroke registry, patients who were hospitalized because of ischemic stroke and had relevant lesions on MRI were selected. Patients who were using anticoagulants or whose stroke subtype was categorized as stroke of other determined etiology or undetermined etiology were excluded. Baseline stroke severity was measured using the National Institutes of Health Stroke Scale scores at presentation and was compared between no previous antiplatelet users and previous antiplatelet users with stratification by stroke subtypes. RESULTS: Among the 1622 patients, a total of 490 (30.2%) patients reported use of an antiplatelet within 1 week of stroke onset. The baseline National Institutes of Health Stroke Scale score showed no difference between the nonantiplatelet and antiplatelet groups by crude comparison. However, the interaction between previous antiplatelet use and stroke subtype was significant (P≤0.023) in a multivariable analysis; when the study subjects were stratified by stroke subtype, the difference in baseline National Institutes of Health Stroke Scale between the nonantiplatelet and platelet groups was significant in the large artery atherothrombosis group but not in those with cardioembolism and small-vessel occlusion before and after adjustments. Conclusions: Our study suggests that the reduction of initial stroke severity in the previous antiplatelet users may differ by stroke mechanism.

KW - Antiplatelet drugs

KW - Cerebral infarction

KW - Stroke classification

UR - http://www.scopus.com/inward/record.url?scp=77953233046&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953233046&partnerID=8YFLogxK

U2 - 10.1161/STROKEAHA.110.580225

DO - 10.1161/STROKEAHA.110.580225

M3 - Article

C2 - 20431078

AN - SCOPUS:77953233046

VL - 41

SP - 1200

EP - 1204

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 6

ER -