Differential effect of previous antiplatelet use on stroke severity according to stroke mechanism

Wook Joo Kim, Youngchai Ko, Mi Hwa Yang, Sun Hye Im, Jung Hyun Park, Jisung Lee, Juneyoung Lee, Moon Ku Han, Hee Joon Bae

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13 Citations (Scopus)

Abstract

Background and Purpose: The effect of previous antiplatelet use on stroke severity is controversial. We assume that this controversy is attributable to its difference according to the stroke mechanism. Methods: Using a prospective stroke registry, patients who were hospitalized because of ischemic stroke and had relevant lesions on MRI were selected. Patients who were using anticoagulants or whose stroke subtype was categorized as stroke of other determined etiology or undetermined etiology were excluded. Baseline stroke severity was measured using the National Institutes of Health Stroke Scale scores at presentation and was compared between no previous antiplatelet users and previous antiplatelet users with stratification by stroke subtypes. RESULTS: Among the 1622 patients, a total of 490 (30.2%) patients reported use of an antiplatelet within 1 week of stroke onset. The baseline National Institutes of Health Stroke Scale score showed no difference between the nonantiplatelet and antiplatelet groups by crude comparison. However, the interaction between previous antiplatelet use and stroke subtype was significant (P≤0.023) in a multivariable analysis; when the study subjects were stratified by stroke subtype, the difference in baseline National Institutes of Health Stroke Scale between the nonantiplatelet and platelet groups was significant in the large artery atherothrombosis group but not in those with cardioembolism and small-vessel occlusion before and after adjustments. Conclusions: Our study suggests that the reduction of initial stroke severity in the previous antiplatelet users may differ by stroke mechanism.

Original languageEnglish
Pages (from-to)1200-1204
Number of pages5
JournalStroke
Volume41
Issue number6
DOIs
Publication statusPublished - 2010 Jun 1

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Keywords

  • Antiplatelet drugs
  • Cerebral infarction
  • Stroke classification

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

Cite this

Kim, W. J., Ko, Y., Yang, M. H., Im, S. H., Park, J. H., Lee, J., Lee, J., Han, M. K., & Bae, H. J. (2010). Differential effect of previous antiplatelet use on stroke severity according to stroke mechanism. Stroke, 41(6), 1200-1204. https://doi.org/10.1161/STROKEAHA.110.580225