Differential expression of ezrin in epithelial skin tumors

Cytoplasmic ezrin immunoreactivity in squamous cell carcinoma

Hye Rim Park, Soo Kee Min, Kwangseon Min, Sun Young Jun, Jinwon Seo, Kwang Ho Kim, Jae Wook Choi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Ezrin is a cytoskeleton linker protein that is actively involved in regulating the growth and metastatic capacity of cancer cells. The purpose of the study was to assess the expression pattern of ezrin in normal skin and various epithelial neoplasms. Methods: We used immunohistochemical techniques to examine the expression of ezrin in paraffin-embedded tissues of squamous cell carcinoma (. n = 23), basal cell carcinoma (. n = 10), Bowen's disease (. n = 10), actinic keratosis (. n = 10), keratoacanthoma (. n = 9), seborrheic keratosis (. n = 5), psoriasis vulgaris (. n = 5), and normal control skin (. n = 5). Results: In Bowen's disease, actinic keratosis, keratoacanthoma, and seborrheic keratosis, ezrin was dominantly expressed in the cell membrane except for the cornified layer. In squamous cell carcinoma (SCC) specimens, the percentage of ezrin-positive cells was increased compared with Bowen's disease, actinic keratosis, keratoacanthoma, and seborrheic keratosis. Especially in SCC samples, ezrin expression was markedly expressed in the cytoplasm. In addition, there was a correlation between the pattern of ezrin expression and tumor differentiation in SCC. Basal cell carcinoma showed intense and diffuse staining especially in the solid growth pattern. Conclusions: Our findings suggest that dysregulation of ezrin may be important in the development of cutaneous epithelial malignancies and tumor grade. We suggest that the cytoplasmic localization of ezrin may be useful in the diagnosis of skin SCC.

Original languageEnglish
Pages (from-to)48-52
Number of pages5
JournalInternational Journal of Dermatology
Volume49
Issue number1
DOIs
Publication statusPublished - 2010 Jan 1

Fingerprint

Squamous Cell Carcinoma
Skin
Seborrheic Keratosis
Keratoacanthoma
Bowen's Disease
Actinic Keratosis
Neoplasms
Basal Cell Carcinoma
ezrin
Glandular and Epithelial Neoplasms
Growth
Cytoskeleton
Psoriasis
Paraffin
Cytoplasm
Cell Membrane
Staining and Labeling
Proteins

ASJC Scopus subject areas

  • Dermatology

Cite this

Differential expression of ezrin in epithelial skin tumors : Cytoplasmic ezrin immunoreactivity in squamous cell carcinoma. / Park, Hye Rim; Min, Soo Kee; Min, Kwangseon; Jun, Sun Young; Seo, Jinwon; Kim, Kwang Ho; Choi, Jae Wook.

In: International Journal of Dermatology, Vol. 49, No. 1, 01.01.2010, p. 48-52.

Research output: Contribution to journalArticle

Park, Hye Rim ; Min, Soo Kee ; Min, Kwangseon ; Jun, Sun Young ; Seo, Jinwon ; Kim, Kwang Ho ; Choi, Jae Wook. / Differential expression of ezrin in epithelial skin tumors : Cytoplasmic ezrin immunoreactivity in squamous cell carcinoma. In: International Journal of Dermatology. 2010 ; Vol. 49, No. 1. pp. 48-52.
@article{0cdbe1b2c72f40758438539c9e1e70e9,
title = "Differential expression of ezrin in epithelial skin tumors: Cytoplasmic ezrin immunoreactivity in squamous cell carcinoma",
abstract = "Background: Ezrin is a cytoskeleton linker protein that is actively involved in regulating the growth and metastatic capacity of cancer cells. The purpose of the study was to assess the expression pattern of ezrin in normal skin and various epithelial neoplasms. Methods: We used immunohistochemical techniques to examine the expression of ezrin in paraffin-embedded tissues of squamous cell carcinoma (. n = 23), basal cell carcinoma (. n = 10), Bowen's disease (. n = 10), actinic keratosis (. n = 10), keratoacanthoma (. n = 9), seborrheic keratosis (. n = 5), psoriasis vulgaris (. n = 5), and normal control skin (. n = 5). Results: In Bowen's disease, actinic keratosis, keratoacanthoma, and seborrheic keratosis, ezrin was dominantly expressed in the cell membrane except for the cornified layer. In squamous cell carcinoma (SCC) specimens, the percentage of ezrin-positive cells was increased compared with Bowen's disease, actinic keratosis, keratoacanthoma, and seborrheic keratosis. Especially in SCC samples, ezrin expression was markedly expressed in the cytoplasm. In addition, there was a correlation between the pattern of ezrin expression and tumor differentiation in SCC. Basal cell carcinoma showed intense and diffuse staining especially in the solid growth pattern. Conclusions: Our findings suggest that dysregulation of ezrin may be important in the development of cutaneous epithelial malignancies and tumor grade. We suggest that the cytoplasmic localization of ezrin may be useful in the diagnosis of skin SCC.",
author = "Park, {Hye Rim} and Min, {Soo Kee} and Kwangseon Min and Jun, {Sun Young} and Jinwon Seo and Kim, {Kwang Ho} and Choi, {Jae Wook}",
year = "2010",
month = "1",
day = "1",
doi = "10.1111/j.1365-4632.2009.04191.x",
language = "English",
volume = "49",
pages = "48--52",
journal = "International Journal of Dermatology",
issn = "0011-9059",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Differential expression of ezrin in epithelial skin tumors

T2 - Cytoplasmic ezrin immunoreactivity in squamous cell carcinoma

AU - Park, Hye Rim

AU - Min, Soo Kee

AU - Min, Kwangseon

AU - Jun, Sun Young

AU - Seo, Jinwon

AU - Kim, Kwang Ho

AU - Choi, Jae Wook

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Background: Ezrin is a cytoskeleton linker protein that is actively involved in regulating the growth and metastatic capacity of cancer cells. The purpose of the study was to assess the expression pattern of ezrin in normal skin and various epithelial neoplasms. Methods: We used immunohistochemical techniques to examine the expression of ezrin in paraffin-embedded tissues of squamous cell carcinoma (. n = 23), basal cell carcinoma (. n = 10), Bowen's disease (. n = 10), actinic keratosis (. n = 10), keratoacanthoma (. n = 9), seborrheic keratosis (. n = 5), psoriasis vulgaris (. n = 5), and normal control skin (. n = 5). Results: In Bowen's disease, actinic keratosis, keratoacanthoma, and seborrheic keratosis, ezrin was dominantly expressed in the cell membrane except for the cornified layer. In squamous cell carcinoma (SCC) specimens, the percentage of ezrin-positive cells was increased compared with Bowen's disease, actinic keratosis, keratoacanthoma, and seborrheic keratosis. Especially in SCC samples, ezrin expression was markedly expressed in the cytoplasm. In addition, there was a correlation between the pattern of ezrin expression and tumor differentiation in SCC. Basal cell carcinoma showed intense and diffuse staining especially in the solid growth pattern. Conclusions: Our findings suggest that dysregulation of ezrin may be important in the development of cutaneous epithelial malignancies and tumor grade. We suggest that the cytoplasmic localization of ezrin may be useful in the diagnosis of skin SCC.

AB - Background: Ezrin is a cytoskeleton linker protein that is actively involved in regulating the growth and metastatic capacity of cancer cells. The purpose of the study was to assess the expression pattern of ezrin in normal skin and various epithelial neoplasms. Methods: We used immunohistochemical techniques to examine the expression of ezrin in paraffin-embedded tissues of squamous cell carcinoma (. n = 23), basal cell carcinoma (. n = 10), Bowen's disease (. n = 10), actinic keratosis (. n = 10), keratoacanthoma (. n = 9), seborrheic keratosis (. n = 5), psoriasis vulgaris (. n = 5), and normal control skin (. n = 5). Results: In Bowen's disease, actinic keratosis, keratoacanthoma, and seborrheic keratosis, ezrin was dominantly expressed in the cell membrane except for the cornified layer. In squamous cell carcinoma (SCC) specimens, the percentage of ezrin-positive cells was increased compared with Bowen's disease, actinic keratosis, keratoacanthoma, and seborrheic keratosis. Especially in SCC samples, ezrin expression was markedly expressed in the cytoplasm. In addition, there was a correlation between the pattern of ezrin expression and tumor differentiation in SCC. Basal cell carcinoma showed intense and diffuse staining especially in the solid growth pattern. Conclusions: Our findings suggest that dysregulation of ezrin may be important in the development of cutaneous epithelial malignancies and tumor grade. We suggest that the cytoplasmic localization of ezrin may be useful in the diagnosis of skin SCC.

UR - http://www.scopus.com/inward/record.url?scp=73149125750&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73149125750&partnerID=8YFLogxK

U2 - 10.1111/j.1365-4632.2009.04191.x

DO - 10.1111/j.1365-4632.2009.04191.x

M3 - Article

VL - 49

SP - 48

EP - 52

JO - International Journal of Dermatology

JF - International Journal of Dermatology

SN - 0011-9059

IS - 1

ER -