Differential expression of immune-associated cancer regulatory genes in low- versus high-dose-rate irradiated AKR/J mice

Suk Chul Shin, Kyung Mi Lee, Yu Mi Kang, Kwanghee Kim, Seon Ah Lim, Kwang Hee Yang, Ji Young Kim, Seon Young Nam, Hee Sun Kim

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

AKR/J mice carrying leukemia viral inserts develop thymic lymphoma. Recently, we demonstrated that the incidence of thymic lymphoma was decreased when these mice were raised in a low-dose-rate γ-irradiation facility. In contrast, mice irradiated at a high-dose rate developed severe thymic lymphoma and died much earlier. To understand the genetic changes occurred by low- versus high-dose-rate γ-irradiation whole genome microarray was performed. Both groups of mice demonstrated up-regulation of Ifng, Igbp1, and IL7 in their thymuses, however, mice exposed to high-dose-rate γ-irradiation exhibited marked down-regulation of Sp3, Il15, Traf6, IL2ra, Pik3r1, and Hells. In contrast, low-dose-rate irradiated mice demonstrated up-regulation of Il15 and Jag2. These gene expression profiles imply the impaired immune signaling pathways by high-dose-rate γ-irradiation while the facilitation of anti-tumor immune responses by low-dose-rate γ-irradiation. Therefore, our data delineate common and distinct immune-associated pathways downstream of low- versus high-dose-rate irradiation in the process of cancer progression in AKR/J mice.

Original languageEnglish
Pages (from-to)358-363
Number of pages6
JournalGenomics
Volume97
Issue number6
DOIs
Publication statusPublished - 2011 Jun

Keywords

  • AKR/J mice
  • Immune-associated genes
  • Low-dose-rate irradiation
  • Thymic lymphoma

ASJC Scopus subject areas

  • Genetics

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  • Cite this

    Shin, S. C., Lee, K. M., Kang, Y. M., Kim, K., Lim, S. A., Yang, K. H., Kim, J. Y., Nam, S. Y., & Kim, H. S. (2011). Differential expression of immune-associated cancer regulatory genes in low- versus high-dose-rate irradiated AKR/J mice. Genomics, 97(6), 358-363. https://doi.org/10.1016/j.ygeno.2011.01.005