Abstract
AKR/J mice carrying leukemia viral inserts develop thymic lymphoma. Recently, we demonstrated that the incidence of thymic lymphoma was decreased when these mice were raised in a low-dose-rate γ-irradiation facility. In contrast, mice irradiated at a high-dose rate developed severe thymic lymphoma and died much earlier. To understand the genetic changes occurred by low- versus high-dose-rate γ-irradiation whole genome microarray was performed. Both groups of mice demonstrated up-regulation of Ifng, Igbp1, and IL7 in their thymuses, however, mice exposed to high-dose-rate γ-irradiation exhibited marked down-regulation of Sp3, Il15, Traf6, IL2ra, Pik3r1, and Hells. In contrast, low-dose-rate irradiated mice demonstrated up-regulation of Il15 and Jag2. These gene expression profiles imply the impaired immune signaling pathways by high-dose-rate γ-irradiation while the facilitation of anti-tumor immune responses by low-dose-rate γ-irradiation. Therefore, our data delineate common and distinct immune-associated pathways downstream of low- versus high-dose-rate irradiation in the process of cancer progression in AKR/J mice.
| Original language | English |
|---|---|
| Pages (from-to) | 358-363 |
| Number of pages | 6 |
| Journal | Genomics |
| Volume | 97 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2011 Jun 1 |
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Keywords
- AKR/J mice
- Immune-associated genes
- Low-dose-rate irradiation
- Thymic lymphoma
ASJC Scopus subject areas
- Genetics
Cite this
Differential expression of immune-associated cancer regulatory genes in low- versus high-dose-rate irradiated AKR/J mice. / Shin, Suk Chul; Lee, Kyung-Mi; Kang, Yu Mi; Kim, Kwanghee; Lim, Seon Ah; Yang, Kwang Hee; Kim, Ji Young; Nam, Seon Young; Kim, Hee Sun.
In: Genomics, Vol. 97, No. 6, 01.06.2011, p. 358-363.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differential expression of immune-associated cancer regulatory genes in low- versus high-dose-rate irradiated AKR/J mice
AU - Shin, Suk Chul
AU - Lee, Kyung-Mi
AU - Kang, Yu Mi
AU - Kim, Kwanghee
AU - Lim, Seon Ah
AU - Yang, Kwang Hee
AU - Kim, Ji Young
AU - Nam, Seon Young
AU - Kim, Hee Sun
PY - 2011/6/1
Y1 - 2011/6/1
N2 - AKR/J mice carrying leukemia viral inserts develop thymic lymphoma. Recently, we demonstrated that the incidence of thymic lymphoma was decreased when these mice were raised in a low-dose-rate γ-irradiation facility. In contrast, mice irradiated at a high-dose rate developed severe thymic lymphoma and died much earlier. To understand the genetic changes occurred by low- versus high-dose-rate γ-irradiation whole genome microarray was performed. Both groups of mice demonstrated up-regulation of Ifng, Igbp1, and IL7 in their thymuses, however, mice exposed to high-dose-rate γ-irradiation exhibited marked down-regulation of Sp3, Il15, Traf6, IL2ra, Pik3r1, and Hells. In contrast, low-dose-rate irradiated mice demonstrated up-regulation of Il15 and Jag2. These gene expression profiles imply the impaired immune signaling pathways by high-dose-rate γ-irradiation while the facilitation of anti-tumor immune responses by low-dose-rate γ-irradiation. Therefore, our data delineate common and distinct immune-associated pathways downstream of low- versus high-dose-rate irradiation in the process of cancer progression in AKR/J mice.
AB - AKR/J mice carrying leukemia viral inserts develop thymic lymphoma. Recently, we demonstrated that the incidence of thymic lymphoma was decreased when these mice were raised in a low-dose-rate γ-irradiation facility. In contrast, mice irradiated at a high-dose rate developed severe thymic lymphoma and died much earlier. To understand the genetic changes occurred by low- versus high-dose-rate γ-irradiation whole genome microarray was performed. Both groups of mice demonstrated up-regulation of Ifng, Igbp1, and IL7 in their thymuses, however, mice exposed to high-dose-rate γ-irradiation exhibited marked down-regulation of Sp3, Il15, Traf6, IL2ra, Pik3r1, and Hells. In contrast, low-dose-rate irradiated mice demonstrated up-regulation of Il15 and Jag2. These gene expression profiles imply the impaired immune signaling pathways by high-dose-rate γ-irradiation while the facilitation of anti-tumor immune responses by low-dose-rate γ-irradiation. Therefore, our data delineate common and distinct immune-associated pathways downstream of low- versus high-dose-rate irradiation in the process of cancer progression in AKR/J mice.
KW - AKR/J mice
KW - Immune-associated genes
KW - Low-dose-rate irradiation
KW - Thymic lymphoma
UR - http://www.scopus.com/inward/record.url?scp=79957445043&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79957445043&partnerID=8YFLogxK
U2 - 10.1016/j.ygeno.2011.01.005
DO - 10.1016/j.ygeno.2011.01.005
M3 - Article
VL - 97
SP - 358
EP - 363
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 6
ER -