Differential expression of immune-associated cancer regulatory genes in low- versus high-dose-rate irradiated AKR/J mice

Suk Chul Shin, Kyung-Mi Lee, Yu Mi Kang, Kwanghee Kim, Seon Ah Lim, Kwang Hee Yang, Ji Young Kim, Seon Young Nam, Hee Sun Kim

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

AKR/J mice carrying leukemia viral inserts develop thymic lymphoma. Recently, we demonstrated that the incidence of thymic lymphoma was decreased when these mice were raised in a low-dose-rate γ-irradiation facility. In contrast, mice irradiated at a high-dose rate developed severe thymic lymphoma and died much earlier. To understand the genetic changes occurred by low- versus high-dose-rate γ-irradiation whole genome microarray was performed. Both groups of mice demonstrated up-regulation of Ifng, Igbp1, and IL7 in their thymuses, however, mice exposed to high-dose-rate γ-irradiation exhibited marked down-regulation of Sp3, Il15, Traf6, IL2ra, Pik3r1, and Hells. In contrast, low-dose-rate irradiated mice demonstrated up-regulation of Il15 and Jag2. These gene expression profiles imply the impaired immune signaling pathways by high-dose-rate γ-irradiation while the facilitation of anti-tumor immune responses by low-dose-rate γ-irradiation. Therefore, our data delineate common and distinct immune-associated pathways downstream of low- versus high-dose-rate irradiation in the process of cancer progression in AKR/J mice.

Original languageEnglish
Pages (from-to)358-363
Number of pages6
JournalGenomics
Volume97
Issue number6
DOIs
Publication statusPublished - 2011 Jun 1

Fingerprint

Inbred AKR Mouse
Neoplasm Genes
Regulator Genes
Interleukin-15
Lymphoma
Up-Regulation
Interleukin-7
Transcriptome
Thymus Gland
Neoplasms
Leukemia
Down-Regulation
Genome
Incidence

Keywords

  • AKR/J mice
  • Immune-associated genes
  • Low-dose-rate irradiation
  • Thymic lymphoma

ASJC Scopus subject areas

  • Genetics

Cite this

Differential expression of immune-associated cancer regulatory genes in low- versus high-dose-rate irradiated AKR/J mice. / Shin, Suk Chul; Lee, Kyung-Mi; Kang, Yu Mi; Kim, Kwanghee; Lim, Seon Ah; Yang, Kwang Hee; Kim, Ji Young; Nam, Seon Young; Kim, Hee Sun.

In: Genomics, Vol. 97, No. 6, 01.06.2011, p. 358-363.

Research output: Contribution to journalArticle

Shin, Suk Chul ; Lee, Kyung-Mi ; Kang, Yu Mi ; Kim, Kwanghee ; Lim, Seon Ah ; Yang, Kwang Hee ; Kim, Ji Young ; Nam, Seon Young ; Kim, Hee Sun. / Differential expression of immune-associated cancer regulatory genes in low- versus high-dose-rate irradiated AKR/J mice. In: Genomics. 2011 ; Vol. 97, No. 6. pp. 358-363.
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