Differential methylation pattern of ID4, SFRP1, and SHP1 between acute myeloid leukemia and chronic myeloid leukemia

Kyung Ok Uhm, Eun Soo Lee, Yun Mi Lee, Jeong Seon Park, Seok Jin Kim, Byung Soo Kim, Hyeon Soo Kim, Sun Hwa Park

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

To gain insight into the differential mechanism of gene promoter hypermethylation in acute and chronic leukemia, we identified the methylation status on one part of 5'CpG rich region of 8 genes, DAB2IP, DLC-1, H-cadherin, ID4, Integrin α4, RUNX3, SFRP1, and SHP1 in bone marrows from acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) patients. Also, we compared the methylation status of genes in AML and CML using methylation-specific PCR (MSP). The frequencies of DNA methylation of ID4, SFRP1, and SHP1 were higher in AML patients compared to those in CML patients. In contrast, no statistical difference between AML and CML was detected for other genes such as DLC-1, DAB2IP, H-cadherin, Integrin α4, and RUNX3. Taken together, these results suggest that these methylation-controlled genes may have different roles in AML and CML, and thus, may act as a biological marker of AML.

Original languageEnglish
Pages (from-to)493-497
Number of pages5
JournalJournal of Korean medical science
Volume24
Issue number3
DOIs
Publication statusPublished - 2009 Jun 1

Keywords

  • Acute
  • BCR-ABL positive
  • Chronic
  • DNA methylation
  • Leukemia
  • Myeloid

ASJC Scopus subject areas

  • Medicine(all)

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