Differential regulation of EIN3 stability by glucose and ethylene signalling in plants

Shuichi Yanagisawa, Sang-Dong Yoo, Jen Sheen

Research output: Contribution to journalArticle

342 Citations (Scopus)

Abstract

Glucose is a global regulator of growth and metabolism that is evolutionarily conserved from unicellular microorganisms to multicellular animals and plants. In photosynthetic plants, glucose shows hormone-like activities and modulates many essential processes, including embryogenesis, germination, seedling development, vegetative growth, reproduction and senescence. Genetic and phenotypic analyses of Arabidopsis mutants with glucose- insensitive (gin) and glucose-oversensitive (glo) phenotypes have identified an unexpected antagonistic interaction between glucose and the plant stress hormone ethylene. The ethylene-insensitive etr1 and ein2 mutants have glo phenotypes, whereas the constitutive ethylene signalling mutant ctr1 is allelic to gin4 (refs 4, 5). The precise molecular mechanisms underlying the complex signalling network that governs plant growth and development in response to nutrients and plant hormones are mostly unknown. Here we show that glucose enhances the degradation of ETHYLENE-INSENSITIVE3 (EIN3), a key transcriptional regulator in ethylene signalling, through the plant glucose sensor hexokinase. Ethylene, by contrast, enhances the stability of EIN3. The ein3 mutant has a glo phenotype, and overexpression of EIN3 in transgenic Arabidopsis decreases glucose sensitivity.

Original languageEnglish
Pages (from-to)521-525
Number of pages5
JournalNature
Volume425
Issue number6957
DOIs
Publication statusPublished - 2003 Oct 2
Externally publishedYes

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Glucose
Plant Growth Regulators
Phenotype
Growth and Development
Arabidopsis
ethylene
Hexokinase
Plant Development
Germination
Seedlings
Embryonic Development
Reproduction
Hormones
Food
Growth

ASJC Scopus subject areas

  • General

Cite this

Differential regulation of EIN3 stability by glucose and ethylene signalling in plants. / Yanagisawa, Shuichi; Yoo, Sang-Dong; Sheen, Jen.

In: Nature, Vol. 425, No. 6957, 02.10.2003, p. 521-525.

Research output: Contribution to journalArticle

Yanagisawa, Shuichi ; Yoo, Sang-Dong ; Sheen, Jen. / Differential regulation of EIN3 stability by glucose and ethylene signalling in plants. In: Nature. 2003 ; Vol. 425, No. 6957. pp. 521-525.
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