Differential regulation of metallothionein-I and metallothionein-II mRNA expression in the rat brain following traumatic brain injury

Eun Hae Kim, Tae Sik Kim, Woong Sun, Dal Soo Kim, Hyun Soo Chung, Dong Ki Kim, Sun-Hwa Park, Hyun Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In this study, we investigated the expression of metallothionein (MT)-I and MT-II in the rat brain following traumatic brain injury (TBI). In the early stage, significant induction of MT-I and MT-II were observed in various regions including ventricle walls, pia mater, and dentate gyrus. At 12-24 h after TBI, strong induction of MT-I mRNA was observed in cerebral cortical layer II/III, amygdala, and piriform cortex where neurons reside. On the other hand, MT-II appeared to be expressed mainly in glial cells localized in the cerebral cortex and hippocampal formation. Three days after TBI, MTs were observed in the vimentin-positive astrocytes in the penumbra as revealed by double immunohistochemistry. The differences in expression of MT-I and MT-II in different brain regions and cell types (neuron vs. glial cells) suggests that multiple regulatory mechanisms are involved in the control of MT expression following brain injury.

Original languageEnglish
Pages (from-to)326-331
Number of pages6
JournalMolecules and Cells
Volume18
Issue number3
Publication statusPublished - 2004 Dec 31

Fingerprint

Metallothionein
Messenger RNA
Brain
Neuroglia
Pia Mater
Traumatic Brain Injury
Neurons
Dentate Gyrus
Vimentin
Amygdala
Astrocytes
Cerebral Cortex
Brain Injuries
Hippocampus
Immunohistochemistry

Keywords

  • Glial cells
  • Metallothioneins
  • Neurons
  • Rat brain
  • Traumatic brain injury

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Differential regulation of metallothionein-I and metallothionein-II mRNA expression in the rat brain following traumatic brain injury. / Kim, Eun Hae; Kim, Tae Sik; Sun, Woong; Kim, Dal Soo; Chung, Hyun Soo; Kim, Dong Ki; Park, Sun-Hwa; Kim, Hyun.

In: Molecules and Cells, Vol. 18, No. 3, 31.12.2004, p. 326-331.

Research output: Contribution to journalArticle

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