Differential regulation of metallothionein-I and metallothionein-II mRNA expression in the rat brain following traumatic brain injury

Eun Hae Kim, Tae Sik Kim, Woong Sun, Dal Soo Kim, Hyun Soo Chung, Dong Ki Kim, Sun Hwa Park, Hyun Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In this study, we investigated the expression of metallothionein (MT)-I and MT-II in the rat brain following traumatic brain injury (TBI). In the early stage, significant induction of MT-I and MT-II were observed in various regions including ventricle walls, pia mater, and dentate gyrus. At 12-24 h after TBI, strong induction of MT-I mRNA was observed in cerebral cortical layer II/III, amygdala, and piriform cortex where neurons reside. On the other hand, MT-II appeared to be expressed mainly in glial cells localized in the cerebral cortex and hippocampal formation. Three days after TBI, MTs were observed in the vimentin-positive astrocytes in the penumbra as revealed by double immunohistochemistry. The differences in expression of MT-I and MT-II in different brain regions and cell types (neuron vs. glial cells) suggests that multiple regulatory mechanisms are involved in the control of MT expression following brain injury.

Original languageEnglish
Pages (from-to)326-331
Number of pages6
JournalMolecules and cells
Volume18
Issue number3
Publication statusPublished - 2004 Dec 31

Keywords

  • Glial cells
  • Metallothioneins
  • Neurons
  • Rat brain
  • Traumatic brain injury

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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