Differential regulation of metallothionein-I, II, and III mRNA expression in the rat brain following kainic acid treatment

Donghou Kim, Eun Hae Kim, Changmee Kim, Woong Sun, Hyun Jung Kim, Chang Sub Uhm, Sun-Hwa Park, Hyun Kim

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Although metallothioneins (MTs) are believed to be involved in the protection against neural stresses, spatio-temporal regulation of MT isoforms following neural insults has not been thoroughly examined. In this study, we found that systemic application of kainic acid (KA) rapidly induced MT-I and II expression in neurons localized in hippocampal formation, piriform cortex, and amygdala of the adult rat, whereas the level of MT-III mRNA was decreased in KA-vulnerable areas. At 96 h after KA treatment, while the neuronal expression of MT-I and II returned to basal level, the glial expression of MT-I, II and III was increased in the reactive astrocytes. Differential regulation of MT isoforms in neuron and gila suggests that each isoform might have distinct role in the cell-type dependent cellular responses against KA-evoked neural injuries.

Original languageEnglish
Pages (from-to)679-682
Number of pages4
JournalNeuroReport
Volume14
Issue number5
DOIs
Publication statusPublished - 2003 Apr 15

Fingerprint

Metallothionein
Kainic Acid
Messenger RNA
Protein Isoforms
Brain
Neurons
Amygdala
Neuroglia
Astrocytes
Hippocampus
growth inhibitory factor
Wounds and Injuries

Keywords

  • Brain
  • Glia
  • Kainic acid
  • Metallothioneins
  • Neuron
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Differential regulation of metallothionein-I, II, and III mRNA expression in the rat brain following kainic acid treatment. / Kim, Donghou; Kim, Eun Hae; Kim, Changmee; Sun, Woong; Kim, Hyun Jung; Uhm, Chang Sub; Park, Sun-Hwa; Kim, Hyun.

In: NeuroReport, Vol. 14, No. 5, 15.04.2003, p. 679-682.

Research output: Contribution to journalArticle

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