Differential regulation of metallothionein-I, II, and III mRNA expression in the rat brain following kainic acid treatment

Donghou Kim, Eun Hae Kim, Changmee Kim, Woong Sun, Hyun Jung Kim, Chang Sub Uhm, Sun Hwa Park, Hyun Kim

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Although metallothioneins (MTs) are believed to be involved in the protection against neural stresses, spatio-temporal regulation of MT isoforms following neural insults has not been thoroughly examined. In this study, we found that systemic application of kainic acid (KA) rapidly induced MT-I and II expression in neurons localized in hippocampal formation, piriform cortex, and amygdala of the adult rat, whereas the level of MT-III mRNA was decreased in KA-vulnerable areas. At 96 h after KA treatment, while the neuronal expression of MT-I and II returned to basal level, the glial expression of MT-I, II and III was increased in the reactive astrocytes. Differential regulation of MT isoforms in neuron and gila suggests that each isoform might have distinct role in the cell-type dependent cellular responses against KA-evoked neural injuries.

Original languageEnglish
Pages (from-to)679-682
Number of pages4
JournalNeuroreport
Volume14
Issue number5
DOIs
Publication statusPublished - 2003 Apr 15

Keywords

  • Brain
  • Glia
  • Kainic acid
  • Metallothioneins
  • Neuron
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

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