Differential reorganization of fusiform gyrus in two types of Alexia after stroke

Sung Bom Pyun, Hyo Jeong Sohn, Jae Bum Jung, Kichun Nam

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Lesions affecting the left fusiform gyrus (FG) commonly result in dyslexia and recovery largely depends on efficient reorganization of the reading network. We performed a follow-up fMRI study to elucidate the reorganization patterns of the FG according to the recovery of reading ability in two patients (MH with pure alexia and KM with alexia with agraphia) after stroke involving the left FG. Initially, MH was an effortful letter-by-letter (LBL) reader, and she improved to become a proficient LBL reader. The initial fMRI results showed scattered activation on occipital and ventral temporal cortex during reading, which was localized to right FG in the follow-up study. KM's severe alexia with agraphia did not improve, even after 6 months had passed since the onset of the alexia. The initial and follow-up fMRI results showed no significant activation in the bilateral FG or central higher language areas during word reading. Our results suggest that the reorganization of the FG is different according to the type of alexia and the amount of clinical recovery in each patient. Also, the successful reorganization of the visual component of reading in the right FG is responsible for the recovery of LBL reading in pure alexia.

Original languageEnglish
Pages (from-to)417-425
Number of pages9
JournalNeurocase
Volume13
Issue number5-6
DOIs
Publication statusPublished - 2007 Dec 1

Fingerprint

Dyslexia
Temporal Lobe
Stroke
Reading
Pure Alexia
Agraphia
Magnetic Resonance Imaging
Aptitude
Letters
Alexia
Reorganization
Language
Recovery
Functional Magnetic Resonance Imaging

Keywords

  • Alexia with agraphia
  • Functional MRI
  • Fusiform gyrus
  • Pure alexia
  • Visual word form area

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

Differential reorganization of fusiform gyrus in two types of Alexia after stroke. / Pyun, Sung Bom; Sohn, Hyo Jeong; Jung, Jae Bum; Nam, Kichun.

In: Neurocase, Vol. 13, No. 5-6, 01.12.2007, p. 417-425.

Research output: Contribution to journalArticle

Pyun, Sung Bom ; Sohn, Hyo Jeong ; Jung, Jae Bum ; Nam, Kichun. / Differential reorganization of fusiform gyrus in two types of Alexia after stroke. In: Neurocase. 2007 ; Vol. 13, No. 5-6. pp. 417-425.
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