Differential Toxicokinetics Determines the Sensitivity of Two Marine Embryonic Fish Exposed to Iranian Heavy Crude Oil

Jee Hyun Jung, Moonkoo Kim, Un Hyuk Yim, Sung Yong Ha, Won Joon Shim, Young Sun Chae, Hana Kim, John P. Incardona, Tiffany L. Linbo, Jung-Hwan Kwon

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Interspecific difference in the developmental toxicity of crude oil to embryonic fish allows the prediction of injury extent to a number of resident fish species in oil spill sites. This study clarifies the comparative developmental effects of Iranian heavy crude oil (IHCO) on the differences of biouptake and toxic sensitivity between embryonic spotted sea bass (Lateolabrax maculates) and olive flounder (Paralichthys olivaceus). From 24 h after exposure to IHCO, several morphological defects were observed in both species of embryonic fish, including pericardial edema, dorsal curvature of the trunk, developmental delay, and reduced finfolds. The severity of defects was greater in flounder compared to that in sea bass. While flounder embryos accumulated higher embryo PAH concentrations than sea bass, the former showed significantly lower levels of CYP1A expression. Although bioconcentration ratios were similar between the two species for some PAHs, phenanthrenes and dibenzothiophenes showed selectively higher bioconcentration ratios in flounder, suggesting that this species has a reduced metabolic capacity for these compounds. While consistent with a conserved cardiotoxic mechanism for petrogenic PAHs across diverse marine and freshwater species, these findings indicate that species-specific differences in toxicokinetics can be an important factor underlying species' sensitivity to crude oil.

Original languageEnglish
Pages (from-to)13639-13648
Number of pages10
JournalEnvironmental Science and Technology
Volume49
Issue number22
DOIs
Publication statusPublished - 2015 Oct 12

ASJC Scopus subject areas

  • Chemistry(all)
  • Environmental Chemistry

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    Jung, J. H., Kim, M., Yim, U. H., Ha, S. Y., Shim, W. J., Chae, Y. S., Kim, H., Incardona, J. P., Linbo, T. L., & Kwon, J-H. (2015). Differential Toxicokinetics Determines the Sensitivity of Two Marine Embryonic Fish Exposed to Iranian Heavy Crude Oil. Environmental Science and Technology, 49(22), 13639-13648. https://doi.org/10.1021/acs.est.5b03729