Differing effects of aging on central and peripheral blood pressures and pulse wave velocity: A direct intraarterial study

Cheol Ung Choi, Eung Ju Kim, Seong Hwan Kim, Seung Yong Shin, Un Jung Choi, Jin Won Kim, Hong Euy Lim, Seung Woon Rha, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Objectives: There have been a few noninvasive studies showing the effect of aging on blood pressure (BP) and pulse wave velocity (PWV) in different arterial segments. The aim of this study was to evaluate the effect of aging on arterial hemodynamics in central and peripheral arteries using an invasive method. Methods: We observed 175 individuals undergoing coronary angiography. SBP and DBP were measured by pressure wave at the radial artery, abdominal aorta, and aortic arch. Aortic arch-abdominal aorta PWV (aoPWV) and aortic arch-radial artery PWV (arPWV) were also assessed by the foot-to-foot velocity method using a fluid-filled system. Results: SBP and pulse pressure were significantly positively correlated and DBP was significantly negatively correlated with age through the arterial tree in a multivariate analysis after adjusting for sex, coronary artery disease, diabetes, dyslipidemia, smoking status, and the use of antihypertensive agents. Pulse pressure, SBP, and DBP were significantly associated with age (ranked in order of association strength) at all studied arterial segments. Each central BP showed a consistently higher correlation with age than radial BP. aoPWV and arPWV were also significantly correlated with age, and this relationship was much stronger for aoPWV (r = 0.474, P < 0.001) than for arPWV (r = 0.224, P = 0.003). Conclusion: The present invasive study suggests that aging has a greater effect on central rather than peripheral arterial hemodynamics. The central pulse pressure was the predominant BP affected by aging, which could be caused by the stronger relationship of aging with central arterial stiffness.

Original languageEnglish
Pages (from-to)1252-1260
Number of pages9
JournalJournal of Hypertension
Issue number6
Publication statusPublished - 2010 Jun


  • Aging
  • Aorta
  • Blood pressure
  • Pulse wave velocity
  • Radial artery

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


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