Diffusion compartmentalization using response function groups with cardinality penalization

Pew Thian Yap, Yong Zhang, Dinggang Shen

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Spherical deconvolution (SD) of the white matter (WM) diffusion-attenuated signal with a fiber signal response function has been shown to yield high-quality estimates of fiber orientation distribution functions (FODFs). However, an inherent limitation of this approach is that the response function (RF) is often fixed and assumed to be spatially invariant. This has been reported to result in spurious FODF peaks as the discrepancy of the RF with the data increases. In this paper, we propose to utilize response function groups (RFGs) for robust compartmentalization of diffusion signal and hence improving FODF estimation. Unlike the aforementioned single fixed RF, each RFG consists of a set of RFs that are intentionally varied to capture potential signal variations associated with a fiber bundle. Additional isotropic RFGs are included to account for signal contributions from gray matter (GM) and cerebrospinal fluid (CSF). To estimate the WM FODF and the volume fractions of GM and CSF compartments, the RFGs are fitted to the data in the least-squares sense, penalized by the cardinality of the support of the solution to encourage group sparsity. The volume fractions associated with each compartment are then computed by summing up the volume fractions of the RFs within each RFGs. Experimental results confirm that our method yields estimates of FODFs and volume fractions of diffusion compartments with improved robustness and accuracy.

Original languageEnglish
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
PublisherSpringer Verlag
Pages183-190
Number of pages8
Volume9349
DOIs
Publication statusPublished - 2015
Externally publishedYes

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9349
ISSN (Print)03029743
ISSN (Electronic)16113349

Fingerprint

Penalization
Response Function
Cardinality
Fiber Orientation
Fiber reinforced materials
Distribution functions
Distribution Function
Volume Fraction
Volume fraction
Cerebrospinal fluid
Estimate
Fluid
Function Estimation
Fibers
Fiber Bundle
Deconvolution
Sparsity
Discrepancy
Least Squares
Fiber

ASJC Scopus subject areas

  • Computer Science(all)
  • Theoretical Computer Science

Cite this

Yap, P. T., Zhang, Y., & Shen, D. (2015). Diffusion compartmentalization using response function groups with cardinality penalization. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 9349, pp. 183-190). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 9349). Springer Verlag. https://doi.org/10.1007/978-3-319-24553-9_23

Diffusion compartmentalization using response function groups with cardinality penalization. / Yap, Pew Thian; Zhang, Yong; Shen, Dinggang.

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 9349 Springer Verlag, 2015. p. 183-190 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 9349).

Research output: Chapter in Book/Report/Conference proceedingChapter

Yap, PT, Zhang, Y & Shen, D 2015, Diffusion compartmentalization using response function groups with cardinality penalization. in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). vol. 9349, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 9349, Springer Verlag, pp. 183-190. https://doi.org/10.1007/978-3-319-24553-9_23
Yap PT, Zhang Y, Shen D. Diffusion compartmentalization using response function groups with cardinality penalization. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 9349. Springer Verlag. 2015. p. 183-190. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). https://doi.org/10.1007/978-3-319-24553-9_23
Yap, Pew Thian ; Zhang, Yong ; Shen, Dinggang. / Diffusion compartmentalization using response function groups with cardinality penalization. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 9349 Springer Verlag, 2015. pp. 183-190 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).
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